{"id":"W2312853034","doi":"10.1021/mp500104j","title":"Structural Modifications of Mitochondria-Targeted Chlorambucil Alter Cell Death Mechanism but Preserve MDR Evasion","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chlorambucil; Mitochondrion; Programmed cell death; Cytosol; Apoptosis; Cell biology; Multiple drug resistance; Chemistry; Cancer cell; Cell; Biology; Cancer research; Biochemistry; Cancer; Enzyme; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007509953,0.0002213917,0.0001238999,0.0001023947,0.00009978435,0.0001335528,0.0001691085,0.000187614,0.0005889724],"category_scores_gemma":[0.0001375937,0.00006694372,0.0001410044,0.00008011871,0.0001765952,0.0001659416,0.00009919197,0.0003457181,0.0001105186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222893,"about_ca_system_score_gemma":0.0001662863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004853753,"about_ca_topic_score_gemma":0.0007683237,"domain_scores_codex":[0.9999392,0.00001293476,0.000004955694,0.0000113841,0.00001383118,0.0000176236],"domain_scores_gemma":[0.9999281,0.00001205526,0.00002933112,0.0000109135,0.00001129659,0.00000830851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005507126,0.00001094855,0.00009301837,0.00002594626,0.000003529534,0.0000215677,0.000009271826,0.00007675432,0.9988538,0.00007437347,0.000009469857,0.0007660588],"study_design_scores_gemma":[0.00000677022,0.0002192128,0.0007818888,0.000002559018,0.000009060559,0.00007984215,0.000005687499,0.0001645636,0.9977996,0.00001791698,0.0009106554,0.000002307541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963824,0.00109853,0.001638883,0.00005713192,0.000008815943,0.00002318062,0.00007586744,0.00002567893,0.000689483],"genre_scores_gemma":[0.9977745,0.0005697348,0.001189532,0.00003469459,0.000003086591,0.00001150244,0.00006431287,0.000006377037,0.0003462349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005889724,"threshold_uncertainty_score":0.001970351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03212110513796085,"score_gpt":0.2968432610939384,"score_spread":0.2647221559559775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}