{"id":"W2312885292","doi":"10.1152/ajpheart.00729.2011","title":"A selective phosphodiesterase 3 inhibitor rescues low P<scp>o</scp><sub>2</sub>-induced ATP release from erythrocytes of humans with type 2 diabetes: implication for vascular control","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; Saint Louis University; American Diabetes Association","keywords":"Cilostazol; Skeletal muscle; Chemistry; Phosphodiesterase inhibitor; Phosphodiesterase; Mastoparan; Phosphodiesterase 3; Internal medicine; Biochemistry; Endocrinology; Biology; Enzyme; Medicine; G protein; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001448223,0.000276347,0.0004675519,0.0001515045,0.0001730882,0.0002739958,0.0001913574,0.0003770532,0.001181489],"category_scores_gemma":[0.0001078345,0.0001430926,0.0003335235,0.0001024496,0.0002075828,0.0001205245,0.0001786342,0.0008162969,0.0001901994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811913,"about_ca_system_score_gemma":0.0001745828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043551,"about_ca_topic_score_gemma":0.001733846,"domain_scores_codex":[0.9999264,0.00001170384,0.000009271282,0.00001741822,0.00001195413,0.00002326059],"domain_scores_gemma":[0.9999361,0.000006631001,0.00001523747,0.000007913158,0.000005596605,0.00002854378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00215311,0.0002006449,0.0006695086,0.00006227726,0.00002569089,0.0001595086,0.00001923746,0.00003468669,0.992768,0.00004461495,0.0001659834,0.00369672],"study_design_scores_gemma":[0.0008307893,0.005414687,0.05891496,0.00002905974,0.0001781876,0.00116876,0.0001541456,0.001444418,0.9253293,0.0001032583,0.006413735,0.00001869062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963128,0.001367041,0.001095584,0.0001525808,0.00005005094,0.00003911052,0.0003924217,0.00004941451,0.0005411555],"genre_scores_gemma":[0.9950976,0.0009086407,0.001621998,0.0002343886,0.00003145582,0.00008042682,0.0006259789,0.00002347645,0.001375991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181489,"threshold_uncertainty_score":0.003952444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00816700114152846,"score_gpt":0.2137735570735101,"score_spread":0.2056065559319816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}