{"id":"W2312970319","doi":"10.1021/ja405916q","title":"Chemical Insight into the Emergence of Influenza Virus Strains That Are Resistant to Relenza","year":2013,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Enzyme kinetics; Neuraminidase; Enzyme; Stereochemistry; Michaelis–Menten kinetics; Sialic acid; Neuraminidase inhibitor; Substrate (aquarium); Catalysis; Hydrolysis; Active site; Biochemistry; Enzyme assay; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146507,0.0001998213,0.0001221944,0.0001972151,0.00005426695,0.0001642667,0.000221435,0.0002923141,0.0007656165],"category_scores_gemma":[0.0001080785,0.0001077765,0.0001761277,0.00008778197,0.0001402832,0.0001250879,0.00008687279,0.000388826,0.00021908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001923833,"about_ca_system_score_gemma":0.000140783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004652647,"about_ca_topic_score_gemma":0.0006466004,"domain_scores_codex":[0.9999474,0.000009307364,0.000003554305,0.000008101052,0.0000173792,0.00001418522],"domain_scores_gemma":[0.9999527,0.00001189531,0.000011617,0.000006561912,0.000009338033,0.000007996389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004552691,0.0000131133,0.0001698609,0.00001316156,0.000002417855,0.00004172859,0.000003201604,0.0001423294,0.9984018,0.0001059807,0.00001164794,0.001049206],"study_design_scores_gemma":[0.00001195978,0.0006849146,0.003064105,0.000003300347,0.00001343227,0.0003004158,0.00001640215,0.001474512,0.9928172,0.0001364884,0.001472052,0.000005354056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862297,0.001973841,0.006429105,0.0001681684,0.00002279563,0.00006579586,0.0005232491,0.00009395799,0.004493478],"genre_scores_gemma":[0.9939476,0.001080207,0.003194928,0.0000766367,0.000005281859,0.00001483109,0.0003985299,0.00001104488,0.001270798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007656165,"threshold_uncertainty_score":0.002561271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05557398052414637,"score_gpt":0.3537986109469505,"score_spread":0.2982246304228042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}