{"id":"W2313123509","doi":"10.1021/cb400675d","title":"Structure Determinants for the Substrate Specificity of Acyl-CoA Δ9 Desaturases from a Marine Copepod","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; National Research Council Canada; Saskatchewan Research Council (Canada)","funders":"","keywords":"Transmembrane domain; Tyrosine; Biochemistry; Residue (chemistry); Transmembrane protein; Mutagenesis; Biology; Stereochemistry; Substrate (aquarium); Chemistry; Amino acid; Mutation; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006155796,0.0001589871,0.0001466468,0.0001390284,0.00006149201,0.0001499542,0.0001009535,0.0001790985,0.0003989247],"category_scores_gemma":[0.0001477879,0.0001156903,0.0002007364,0.0001010218,0.000157764,0.00007615554,0.0001767453,0.0001913789,0.0002238253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001535057,"about_ca_system_score_gemma":0.000119455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004998615,"about_ca_topic_score_gemma":0.0004414374,"domain_scores_codex":[0.9999444,0.000006193522,0.000006282159,0.00001721334,0.0000148179,0.00001105272],"domain_scores_gemma":[0.9998981,0.0000162488,0.0000391079,0.000009939685,0.00001311433,0.00002348255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000572013,0.000003099689,0.001767724,0.00001155645,0.000002816803,0.00006197955,0.00001329427,0.00006823142,0.9976237,0.00002946535,0.000004717163,0.0003560646],"study_design_scores_gemma":[0.0000254574,0.0002103362,0.112914,0.000006413893,0.00002605688,0.001039941,0.0001228044,0.001699415,0.8827179,0.0001035855,0.001122319,0.00001166305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998889,0.0001358765,0.000543951,0.00002042916,0.000003209441,0.000004684263,0.0001035691,0.000007098475,0.0002921107],"genre_scores_gemma":[0.9983788,0.00009540551,0.0008557275,0.00001755774,0.000002160388,0.000005181127,0.0003397354,0.000003418069,0.0003021082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004998615,"threshold_uncertainty_score":0.001334548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105430646627037,"score_gpt":0.2400197658147527,"score_spread":0.229476701152049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}