{"id":"W2313145739","doi":"10.1055/s-2006-945542","title":"MECHANISMS OF TOXICITY IN MITOCHONDRIAL DISEASE","year":2006,"lang":"en","type":"article","venue":"Neuropediatrics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Reactive oxygen species; Medicine; Disease; Toxicity; Mitochondrion; Programmed cell death; Leigh disease; Basal ganglia; Mitochondrial disease; Neuroscience; Pathology; Mitochondrial DNA; Central nervous system; Cell biology; Apoptosis; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001309387,0.0008835311,0.0007167274,0.001648031,0.0007933385,0.00125831,0.001250808,0.001745776,0.002505636],"category_scores_gemma":[0.0007633789,0.0002168565,0.0004583229,0.000403851,0.001364177,0.001636481,0.001588488,0.0009808602,0.0006573597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00108368,"about_ca_system_score_gemma":0.0003491732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002013598,"about_ca_topic_score_gemma":0.0001697767,"domain_scores_codex":[0.9994701,0.0001633488,0.0000559018,0.00007361298,0.0001465925,0.00009054792],"domain_scores_gemma":[0.9993362,0.0001388975,0.0001974685,0.0000519073,0.0001605186,0.0001149604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003059355,0.00119557,0.02410896,0.01252496,0.0009372618,0.02369806,0.002613716,0.007601598,0.4319746,0.1695842,0.02067214,0.3020297],"study_design_scores_gemma":[0.0008052027,0.01084161,0.06141926,0.003503652,0.0009322831,0.08533449,0.002302036,0.007842574,0.2513921,0.295597,0.2797805,0.0002492849],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1838397,0.7614438,0.02301078,0.01000005,0.001464332,0.0002884234,0.0004065948,0.0004010355,0.01914534],"genre_scores_gemma":[0.7451401,0.2378379,0.004908843,0.002110227,0.001619604,0.0002851064,0.0004169297,0.00002802281,0.00765328],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002505636,"threshold_uncertainty_score":0.008382142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007561199885407709,"score_gpt":0.2154373894151935,"score_spread":0.2078761895297858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}