{"id":"W2313145739","doi":"10.1055/s-2006-945542","title":"MECHANISMS OF TOXICITY IN MITOCHONDRIAL DISEASE","year":2006,"lang":"en","type":"article","venue":"Neuropediatrics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Reactive oxygen species; Medicine; Disease; Toxicity; Mitochondrion; Programmed cell death; Leigh disease; Basal ganglia; Mitochondrial disease; Neuroscience; Pathology; Mitochondrial DNA; Central nervous system; Cell biology; Apoptosis; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005707034,0.00009346417,0.000104826,0.00007419613,0.00001849403,0.000005417274,0.0001101582,0.00008461797,0.00003107076],"category_scores_gemma":[0.0001586887,0.00009345664,0.00006600872,0.0001641913,0.00002566934,0.000002047469,0.00005920865,0.0000709068,0.00001400309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004234617,"about_ca_system_score_gemma":0.0000524035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001912449,"about_ca_topic_score_gemma":0.00003407116,"domain_scores_codex":[0.9991924,0.00008577711,0.0002202886,0.0002490593,0.0001054046,0.0001471422],"domain_scores_gemma":[0.9995857,0.00001335287,0.00006958111,0.0002314476,0.00004342094,0.00005649188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000259432,0.0001382394,0.006720693,0.00001424597,0.000001566194,0.0000254402,0.000003080118,0.0003743681,0.9839468,0.002054984,0.006324146,0.0001370278],"study_design_scores_gemma":[0.007147613,0.001820173,0.1088582,0.00001385644,0.000126329,0.00003660026,0.00002398522,0.0003398772,0.6744543,0.009190401,0.196805,0.001183652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97762,0.0001848391,0.01709494,0.00008505768,0.001611815,0.000204362,0.00004362288,0.00001368933,0.003141675],"genre_scores_gemma":[0.9956385,0.00009073511,0.001607173,0.000303095,0.001007202,0.0000101514,0.00008938199,0.00002079624,0.001232994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3094925,"threshold_uncertainty_score":0.3811051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007561199885407709,"score_gpt":0.2154373894151935,"score_spread":0.2078761895297858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}