{"id":"W2313158881","doi":"10.1093/neuonc/nou208.43","title":"TRANSCRIPTIONAL PROFILING OF GBM INVASIVE GENES IDENTIFIES EFFECTIVE INHIBITORS OF THE LIM KINASE-COFILIN PATHWAY","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cell Image Analysis Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Cofilin; Biology; Cancer research; Gene expression profiling; Glioma; Gene; Microarray analysis techniques; Immunohistochemistry; Astrocytoma; Microarray; Pathology; Gene expression; Medicine; Actin cytoskeleton; Genetics; Immunology; Cell; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003795906,0.0001587528,0.0003170153,0.00007907093,0.0000570166,0.000006627545,0.0003098973,0.0002196136,0.00001243074],"category_scores_gemma":[0.0007331509,0.0001266753,0.0002817755,0.0001486932,0.0003425206,0.000006334641,0.000160185,0.0001509191,0.000002054142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002305766,"about_ca_system_score_gemma":0.000150141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002858109,"about_ca_topic_score_gemma":0.0001265107,"domain_scores_codex":[0.9984093,0.0005076512,0.0003940461,0.0003536685,0.0001619249,0.000173351],"domain_scores_gemma":[0.9987441,0.0002566659,0.0003038365,0.000422374,0.0002351099,0.00003788294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007612684,0.0001227193,0.003765187,0.00005381384,0.0000504742,0.000002271026,0.00007331501,0.00003863487,0.99062,0.000144293,0.0004376795,0.004615504],"study_design_scores_gemma":[0.0003489981,0.0007139961,0.001600107,0.00001565105,0.00006616957,0.00001131156,0.00009232203,0.00003422501,0.9861183,0.0001678566,0.01072672,0.0001043316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963241,0.0003052448,0.0007425306,0.0001149428,0.0001639582,0.0004269953,0.00001282163,0.00001480765,0.001894645],"genre_scores_gemma":[0.9986462,0.0001400855,0.0005247158,0.0003339429,0.0001789709,0.00007384158,0.00003669904,0.00002134478,0.00004418384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01028904,"threshold_uncertainty_score":0.5165667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007836307454265322,"score_gpt":0.2506211578571817,"score_spread":0.2427848504029164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}