{"id":"W2313158881","doi":"10.1093/neuonc/nou208.43","title":"TRANSCRIPTIONAL PROFILING OF GBM INVASIVE GENES IDENTIFIES EFFECTIVE INHIBITORS OF THE LIM KINASE-COFILIN PATHWAY","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cell Image Analysis Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Cofilin; Biology; Cancer research; Gene expression profiling; Glioma; Gene; Microarray analysis techniques; Immunohistochemistry; Astrocytoma; Microarray; Pathology; Gene expression; Medicine; Actin cytoskeleton; Genetics; Immunology; Cell; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147046,0.000203163,0.0003321078,0.0004162125,0.0001812855,0.0003436884,0.00008757737,0.00014132,0.0008041403],"category_scores_gemma":[0.0001586622,0.00009854213,0.0002148115,0.0003602521,0.0001618224,0.0001023117,0.0001247209,0.0002416543,0.000212202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002762032,"about_ca_system_score_gemma":0.0002204073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004054841,"about_ca_topic_score_gemma":0.0009441916,"domain_scores_codex":[0.9998691,0.00001067929,0.00000746622,0.00002699658,0.00004254426,0.00004316267],"domain_scores_gemma":[0.999889,0.00002278088,0.00003411268,0.000006545544,0.00002182928,0.00002572854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006734563,0.00008858559,0.01194341,0.0001014735,0.00002256503,0.00005412728,0.00004024969,0.0001639612,0.9824957,0.00004198402,0.0001706996,0.004203707],"study_design_scores_gemma":[0.00005427856,0.001133977,0.2893722,0.00001708104,0.0001169364,0.0005168415,0.0001933442,0.002150033,0.7030348,0.0000921645,0.003307443,0.00001088546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975327,0.0007246215,0.0005410779,0.00003826375,0.00000560229,0.00001745895,0.0006939072,0.00002448133,0.0004218957],"genre_scores_gemma":[0.9954535,0.0005302953,0.001452,0.00005638312,0.000007947067,0.00004188791,0.001817169,0.00001019615,0.0006306194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008041403,"threshold_uncertainty_score":0.002690077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007836307454265322,"score_gpt":0.2506211578571817,"score_spread":0.2427848504029164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}