{"id":"W2313169755","doi":"10.1139/gen-2013-0081","title":"Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder","year":2013,"lang":"en","type":"article","venue":"Genome","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Dalhousie University; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"Wellcome Trust","keywords":"Biology; Bipolar disorder; Exome sequencing; Genetics; Exome; Genetic heterogeneity; Genome-wide association study; Heritability; Population stratification; Candidate gene; Genetic association; Missing heritability problem; Population; Phenotype; Genotype; Gene; Single-nucleotide polymorphism; Medicine; Lithium (medication)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002918916,0.0002988717,0.0004395044,0.0001781512,0.0002263897,0.00007308505,0.0001552725,0.0001648423,0.0003368306],"category_scores_gemma":[0.0001309391,0.0002451951,0.0002443998,0.0002521997,0.0001155947,0.0001657249,0.00005518994,0.0001792355,0.0002468501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002188358,"about_ca_system_score_gemma":0.0002939376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007706324,"about_ca_topic_score_gemma":0.00009420105,"domain_scores_codex":[0.9981505,0.0000884117,0.0003619116,0.0005999064,0.0002792141,0.000520104],"domain_scores_gemma":[0.998579,0.0001180196,0.00009200748,0.0007073231,0.0002892466,0.0002144097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001374082,0.003418092,0.3041821,0.002812756,0.001518578,0.00003681723,0.006682023,0.0003046347,0.6545277,0.0006679787,0.0009806219,0.02349454],"study_design_scores_gemma":[0.004604242,0.0006746792,0.9717309,0.00004833259,0.000352706,0.00002319923,0.0023142,0.000990102,0.001724874,0.001106746,0.01595462,0.0004754024],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582235,0.01760746,0.01796632,0.0006691637,0.0002169012,0.003639787,0.0002175877,0.0001889479,0.001270378],"genre_scores_gemma":[0.9884887,0.00007328386,0.007700234,0.0003861211,0.0001195288,0.0006320971,0.0004629751,0.0000601903,0.002076875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6675487,"threshold_uncertainty_score":0.9998764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02747400771636413,"score_gpt":0.2581153188673241,"score_spread":0.23064131115096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}