{"id":"W2313169755","doi":"10.1139/gen-2013-0081","title":"Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder","year":2013,"lang":"en","type":"article","venue":"Genome","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Dalhousie University; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"Wellcome Trust","keywords":"Biology; Bipolar disorder; Exome sequencing; Genetics; Exome; Genetic heterogeneity; Genome-wide association study; Heritability; Population stratification; Candidate gene; Genetic association; Missing heritability problem; Population; Phenotype; Genotype; Gene; Single-nucleotide polymorphism; Medicine; Lithium (medication)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002622786,0.0002728327,0.0003397559,0.0008453075,0.0004082565,0.0002579265,0.0001799544,0.0004035458,0.00220582],"category_scores_gemma":[0.0008202177,0.0001244811,0.0003392882,0.000555543,0.0001080707,0.0001250505,0.0002391415,0.0003377966,0.0002921857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000141966,"about_ca_system_score_gemma":0.0001544729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001754693,"about_ca_topic_score_gemma":0.00432645,"domain_scores_codex":[0.9998218,0.00003834022,0.00001272186,0.00007570637,0.00003303476,0.00001832454],"domain_scores_gemma":[0.9997743,0.00009754359,0.00004581994,0.00002315039,0.00002604589,0.00003316532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001666415,0.0003197093,0.5093656,0.0002574248,0.001060719,0.01342446,0.0009681589,0.004977585,0.3664386,0.001299743,0.006171666,0.09404994],"study_design_scores_gemma":[0.000103211,0.0004719712,0.9268546,0.00007211758,0.0005706651,0.01779539,0.0004147995,0.02013141,0.02171388,0.00136898,0.01044064,0.00006233856],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831755,0.0006187031,0.01229314,0.000179784,0.00002747585,0.00004554078,0.002608602,0.0001017757,0.0009495036],"genre_scores_gemma":[0.9870529,0.0004401641,0.008966042,0.000234034,0.00002249684,0.00005132447,0.002400332,0.00002754439,0.0008052222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00220582,"threshold_uncertainty_score":0.007379174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02747400771636413,"score_gpt":0.2581153188673241,"score_spread":0.23064131115096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}