{"id":"W2313268045","doi":"10.1021/cb4004942","title":"Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Axela (Canada)","funders":"National Cancer Institute; National Institutes of Health; Bristol-Myers Squibb","keywords":"Antibody; Hapten; Antigen; Phosphorylcholine; Immune system; Immunology; Biology; Population; Effector; Flow cytometry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002104432,0.0003121512,0.0001331301,0.0001437319,0.00005750477,0.0001719472,0.0001803483,0.0002497839,0.000437889],"category_scores_gemma":[0.0001883893,0.0000690391,0.0001499098,0.00009664094,0.000130559,0.0001399292,0.0001633187,0.0002095623,0.0001473785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001910608,"about_ca_system_score_gemma":0.00008116369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001894529,"about_ca_topic_score_gemma":0.0002332261,"domain_scores_codex":[0.9998671,0.00003404245,0.000008554724,0.00002529608,0.00003389324,0.00003108362],"domain_scores_gemma":[0.9999346,0.00002118334,0.00001848495,0.000006136162,0.00001009872,0.000009509514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005476753,0.00001750186,0.0001366069,0.00003362251,0.000003204107,0.0000138173,0.000006881756,0.00009392339,0.9980737,0.00003691943,0.00000638299,0.001522643],"study_design_scores_gemma":[0.000005501801,0.0004919922,0.001092267,0.000003529888,0.000009205746,0.00006419342,0.0000103492,0.0005404948,0.9970504,0.00001693519,0.0007129746,0.000002258266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994393,0.001194714,0.003587079,0.00001999546,0.000004830155,0.00002575531,0.00007549259,0.00001825775,0.0006808487],"genre_scores_gemma":[0.9943445,0.0007725265,0.004092096,0.00005049964,0.000004796767,0.00003109733,0.0001342487,0.000006498195,0.000563845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000437889,"threshold_uncertainty_score":0.001464844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07751751897248864,"score_gpt":0.326065589926898,"score_spread":0.2485480709544093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}