{"id":"W2313268045","doi":"10.1021/cb4004942","title":"Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Axela (Canada)","funders":"National Cancer Institute; National Institutes of Health; Bristol-Myers Squibb","keywords":"Antibody; Hapten; Antigen; Phosphorylcholine; Immune system; Immunology; Biology; Population; Effector; Flow cytometry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007602484,0.0001226717,0.0003116463,0.000108164,0.00008831438,0.000007728354,0.00006509689,0.00007650888,0.00009414325],"category_scores_gemma":[0.0001126695,0.00008730814,0.00006932222,0.0001056916,0.0003770507,0.00007555563,0.0001345233,0.0002221674,0.00004080511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002498521,"about_ca_system_score_gemma":0.00001364798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003452935,"about_ca_topic_score_gemma":6.745109e-7,"domain_scores_codex":[0.9991972,0.00003270479,0.0002106723,0.0002077813,0.00008134117,0.000270303],"domain_scores_gemma":[0.9994757,0.0001899383,0.00004657678,0.0001306361,0.00007063595,0.00008648742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004041138,0.00003006001,0.05608815,0.00009031128,0.0000759357,0.000001991791,0.00004493926,8.750075e-8,0.940558,0.0001408474,0.00002355482,0.002905775],"study_design_scores_gemma":[0.0005877567,0.0002555168,0.04900342,0.0001640704,0.00006087252,0.000120489,0.0001242956,0.0001326076,0.9487831,0.0001411129,0.0004465349,0.0001802421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986455,0.0006690358,0.000003676985,0.0001935079,0.0001166425,0.0001697263,0.0000111598,0.00002160304,0.0001691072],"genre_scores_gemma":[0.9992988,0.00008684098,0.0002762327,0.00002620277,0.000104994,0.00001583392,0.00005489446,0.00001074188,0.0001254322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008225142,"threshold_uncertainty_score":0.3560323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07751751897248864,"score_gpt":0.326065589926898,"score_spread":0.2485480709544093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}