{"id":"W2313384069","doi":"10.1136/heartjnl-2012-302920a.19","title":"ANGIOTENSIN II-MEDIATED MYOCARDIAL EXPRESSION OF MMP2, MMP9 AND MT1-MMP WERE ENHANCED IN ACE2-NULL MICE","year":2012,"lang":"en","type":"article","venue":"Heart","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Angiotensin II; Matrix metalloproteinase; Internal medicine; Endocrinology; MMP2; Zymography; Angiotensin-converting enzyme 2; MMP9; Renin–angiotensin system; Knockout mouse; Medicine; Fibronectin; Metalloproteinase; Gelatinase A; Extracellular matrix; Molecular biology; Chemistry; Biology; Receptor; Downregulation and upregulation; Biochemistry; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003377668,0.001283706,0.000679116,0.0009101207,0.0002698293,0.0005882835,0.0003853719,0.0007351888,0.006061893],"category_scores_gemma":[0.0001759834,0.0005858472,0.0005938635,0.0002590952,0.0005776142,0.000493513,0.0003013156,0.001453203,0.00148231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003210966,"about_ca_system_score_gemma":0.0002228211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004277833,"about_ca_topic_score_gemma":0.0007075746,"domain_scores_codex":[0.999613,0.0000287653,0.00005608774,0.0001283135,0.00009561769,0.00007832631],"domain_scores_gemma":[0.999306,0.00004668272,0.0002552829,0.00004562476,0.00004854424,0.0002977728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002540796,0.00004762214,0.0001411109,0.00003002509,0.000006788385,0.00006688812,0.00001183852,0.0000168592,0.9990627,0.00004151183,0.00002916571,0.0002914835],"study_design_scores_gemma":[0.000129689,0.0007959381,0.009301329,0.00001926075,0.00005881969,0.0008976145,0.00006992796,0.0006648096,0.9856685,0.00008852655,0.002291965,0.00001348391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857166,0.0008826,0.00821018,0.0002403259,0.0001609746,0.00008585248,0.002758042,0.0003592954,0.001586122],"genre_scores_gemma":[0.9619855,0.001223095,0.008375008,0.0001790516,0.00009994378,0.0003210381,0.002219996,0.0003134485,0.02528282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006061893,"threshold_uncertainty_score":0.02027899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007077362220794405,"score_gpt":0.2297313551751478,"score_spread":0.2226539929543534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}