{"id":"W2313384069","doi":"10.1136/heartjnl-2012-302920a.19","title":"ANGIOTENSIN II-MEDIATED MYOCARDIAL EXPRESSION OF MMP2, MMP9 AND MT1-MMP WERE ENHANCED IN ACE2-NULL MICE","year":2012,"lang":"en","type":"article","venue":"Heart","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Angiotensin II; Matrix metalloproteinase; Internal medicine; Endocrinology; MMP2; Zymography; Angiotensin-converting enzyme 2; MMP9; Renin–angiotensin system; Knockout mouse; Medicine; Fibronectin; Metalloproteinase; Gelatinase A; Extracellular matrix; Molecular biology; Chemistry; Biology; Receptor; Downregulation and upregulation; Biochemistry; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759702,0.0001122775,0.0001679913,0.00003651127,0.00003931604,0.000004361879,0.00004763143,0.0001902742,0.00001845739],"category_scores_gemma":[0.00007035342,0.0001044609,0.00005711758,0.00005499176,0.00003669646,0.00000866598,0.0001114504,0.00008153181,0.00000933677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006434575,"about_ca_system_score_gemma":0.00002861417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002902734,"about_ca_topic_score_gemma":0.000005921974,"domain_scores_codex":[0.9992297,0.00006551584,0.0001641006,0.0001948426,0.00009355021,0.000252238],"domain_scores_gemma":[0.999626,0.00001018678,0.00004617494,0.000186357,0.00003422581,0.00009702561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008458886,0.00006066174,0.0008963985,0.00001004482,0.000006124727,6.359419e-7,0.00009259011,6.147463e-7,0.9946563,0.000007638551,0.004040815,0.0001435528],"study_design_scores_gemma":[0.0005277017,0.0001895505,0.002623261,0.00004273855,0.000006106334,0.000007502484,0.00003208769,0.000006336413,0.9793817,0.00002137104,0.01704172,0.0001198976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972127,0.001834876,0.0001073318,0.0001605051,0.0001816251,0.0001791624,0.00001447965,0.000008572522,0.0003007398],"genre_scores_gemma":[0.9982441,0.0001078371,0.0007807481,0.000379283,0.0003028738,0.00001321682,0.00004611986,0.00001454838,0.0001112549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0152746,"threshold_uncertainty_score":0.4259793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007077362220794405,"score_gpt":0.2297313551751478,"score_spread":0.2226539929543534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}