{"id":"W2313442542","doi":"10.5059/yukigoseikyokaishi.66.1093","title":"Synthesis of Potent .ALPHA.v.BETA.3/.ALPHA.IIb.BETA.3 Dual Antagonists Tricyclic Pharmacophore-based Molecules and Their Selectivity Control","year":2008,"lang":"en","type":"article","venue":"Journal of Synthetic Organic Chemistry Japan","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacophore; In vivo; Antagonist; Chemistry; Pharmacology; Stereochemistry; Combinatorial chemistry; Biochemistry; Receptor; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001449033,0.000409361,0.0004710062,0.0001997343,0.0001236194,0.0001769949,0.0003265064,0.0002214451,0.001294145],"category_scores_gemma":[0.0000984727,0.0001867813,0.0002190662,0.0002220064,0.00008522565,0.0001069085,0.0001460312,0.0004230471,0.0007846458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002907196,"about_ca_system_score_gemma":0.0002282219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006299317,"about_ca_topic_score_gemma":0.00116585,"domain_scores_codex":[0.9999015,0.00001203399,0.00001031582,0.00001636453,0.00002013493,0.0000395168],"domain_scores_gemma":[0.9999644,0.000002644258,0.00001015727,0.000002787795,0.000008014867,0.00001210612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002187693,0.0001045261,0.00008325106,0.0001483478,0.00001793572,0.0001793614,0.00004887912,0.0007089266,0.9804026,0.0007323161,0.0006956753,0.01665943],"study_design_scores_gemma":[0.0004715124,0.004717229,0.002365571,0.00003647209,0.0001313894,0.0008385205,0.00003183349,0.004977555,0.9567913,0.0002076448,0.02938351,0.00004752232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9433895,0.008423486,0.02429811,0.0003394276,0.0001674873,0.0009647462,0.001513126,0.0003122395,0.02059193],"genre_scores_gemma":[0.9671158,0.00578032,0.01631944,0.0003221392,0.00006360865,0.0004366882,0.001148878,0.00004013179,0.008772914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294145,"threshold_uncertainty_score":0.004329324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161964116166637,"score_gpt":0.2495458066742033,"score_spread":0.2379261655125369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}