{"id":"W2313442542","doi":"10.5059/yukigoseikyokaishi.66.1093","title":"Synthesis of Potent .ALPHA.v.BETA.3/.ALPHA.IIb.BETA.3 Dual Antagonists Tricyclic Pharmacophore-based Molecules and Their Selectivity Control","year":2008,"lang":"en","type":"article","venue":"Journal of Synthetic Organic Chemistry Japan","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacophore; In vivo; Antagonist; Chemistry; Pharmacology; Stereochemistry; Combinatorial chemistry; Biochemistry; Receptor; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006912294,0.0004867272,0.001372436,0.0002480649,0.0001903307,0.00003068952,0.0003441472,0.0002539016,0.001171376],"category_scores_gemma":[0.0008868743,0.0003800777,0.0005115339,0.0005415376,0.000598482,0.00008450101,0.0000975473,0.0008742689,0.00001136905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003007694,"about_ca_system_score_gemma":0.001016106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001317209,"about_ca_topic_score_gemma":5.669685e-7,"domain_scores_codex":[0.9964576,0.0002077104,0.001166274,0.0004761094,0.001094981,0.0005973564],"domain_scores_gemma":[0.9964225,0.0008925227,0.0008335561,0.0005259238,0.0006227838,0.0007027517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001223186,0.001048717,0.003070944,0.000489108,0.000473396,0.000485311,0.000163363,0.000005551086,0.9824666,9.958592e-7,0.0003140146,0.01025886],"study_design_scores_gemma":[0.004855476,0.0004219758,0.007340706,0.0003353133,0.0004708445,0.007192874,0.0002087978,0.0006775638,0.9776681,0.00001005227,0.0005153878,0.0003029043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942687,0.00146433,0.0004793068,0.002546709,0.00007507872,0.0003401145,0.00004397481,0.00003307427,0.0007487272],"genre_scores_gemma":[0.9980684,0.0009027355,0.0003051514,0.0001241162,0.0002460537,0.000009548718,0.000003732476,0.00009135226,0.0002489079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009955955,"threshold_uncertainty_score":0.9998651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161964116166637,"score_gpt":0.2495458066742033,"score_spread":0.2379261655125369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}