{"id":"W2313474641","doi":"10.1021/ol401036f","title":"Biosynthetic <i>O-</i>Methylation Protects Cladoniamides from Self-destruction","year":2013,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Columbia Knowledge Development Fund","keywords":"Chemistry; Methylation; Heterologous; Methyltransferase; Cytotoxic T cell; DNA methylation; Enzyme; Colorectal cancer; Cell culture; Heterologous expression; DNA methyltransferase; Biochemistry; Gene; Cancer research; Molecular biology; Cell biology; Cancer; Gene expression; Genetics; Recombinant DNA; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00008122162,0.0001684752,0.0002055368,0.00008335022,0.00008883249,0.00005668882,0.00008284747,0.0001128681,0.002119126],"category_scores_gemma":[0.0001080714,0.0001268097,0.00006594393,0.000234275,0.00004839124,0.0001919177,0.00002881334,0.0002139428,0.0009046448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001142627,"about_ca_system_score_gemma":0.00003111941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003136544,"about_ca_topic_score_gemma":0.000005176202,"domain_scores_codex":[0.9989825,0.00005058878,0.0002114437,0.0003469357,0.0001770997,0.000231434],"domain_scores_gemma":[0.9994048,0.00003994176,0.00009112403,0.0003080028,0.00006643767,0.00008963046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001507808,0.0000364036,0.0002945517,0.00003064068,0.00004958624,0.000004189674,0.00009964992,1.465903e-7,0.9864886,0.000006059716,0.003965899,0.009009136],"study_design_scores_gemma":[0.0003818459,0.00005191001,0.0108793,0.00006073029,0.0000834705,0.00003667037,0.00002705143,0.00004563687,0.9855962,0.0001218693,0.002543164,0.0001721621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629424,0.00008825719,0.00007758236,0.03559079,0.0002796817,0.0007130601,0.000004346546,0.000246181,0.00005772466],"genre_scores_gemma":[0.9913301,0.00002826002,0.004195813,0.003803376,0.0005284188,0.000003959726,0.00002574738,0.00003444521,0.00004991936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03178741,"threshold_uncertainty_score":0.9998733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00647609185082566,"score_gpt":0.1932436681973349,"score_spread":0.1867675763465092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}