{"id":"W2313474641","doi":"10.1021/ol401036f","title":"Biosynthetic <i>O-</i>Methylation Protects Cladoniamides from Self-destruction","year":2013,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Columbia Knowledge Development Fund","keywords":"Chemistry; Methylation; Heterologous; Methyltransferase; Cytotoxic T cell; DNA methylation; Enzyme; Colorectal cancer; Cell culture; Heterologous expression; DNA methyltransferase; Biochemistry; Gene; Cancer research; Molecular biology; Cell biology; Cancer; Gene expression; Genetics; Recombinant DNA; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006525459,0.0001833589,0.00009734702,0.00006207482,0.00009590459,0.0001414791,0.0001926005,0.0001330946,0.0007266454],"category_scores_gemma":[0.0001032981,0.00006977608,0.0001071589,0.00007347515,0.0001426387,0.0001187006,0.0001092735,0.0002859105,0.0002412742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002687646,"about_ca_system_score_gemma":0.0002853606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001091544,"about_ca_topic_score_gemma":0.001662908,"domain_scores_codex":[0.9999593,0.000005763759,0.000002840683,0.00000809253,0.00001130535,0.00001265364],"domain_scores_gemma":[0.9999251,0.000008050296,0.00002780136,0.00001490065,0.00001031284,0.0000137207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008123682,0.000006461165,0.0001470714,0.00001968,0.000001681148,0.00002585003,0.000008579431,0.0001054336,0.9981464,0.00008632528,0.00002122707,0.00134999],"study_design_scores_gemma":[0.000006924142,0.0001624989,0.001153748,0.000003032047,0.000003802633,0.00008018595,0.000009792881,0.0002560553,0.9962749,0.00002915537,0.002017584,0.000002317818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905738,0.0007092045,0.00449957,0.00005528953,0.0000116615,0.0000280708,0.000391988,0.00007050634,0.003659885],"genre_scores_gemma":[0.9970709,0.000273085,0.001388216,0.00001694198,0.000001193165,0.000007456083,0.0003201037,0.000009133982,0.0009128992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091544,"threshold_uncertainty_score":0.002430856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00647609185082566,"score_gpt":0.1932436681973349,"score_spread":0.1867675763465092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}