{"id":"W2313477739","doi":"10.1097/yic.0000000000000105","title":"A randomized, double-blinded, placebo-controlled study to evaluate the efficacy and safety of venlafaxine extended release and a long-term extension study for patients with major depressive disorder in Japan","year":2015,"lang":"en","type":"article","venue":"International Clinical Psychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Global Affairs Canada","funders":"Eli Lilly Japan; Meiji Seika Pharma; Shionogi; Pfizer Japan; Abbott Japan; Chugai Pharmaceutical; Mitsubishi Tanabe Pharma Corporation; AbbVie; Novartis Pharma; Otsuka Pharmaceutical; Eisai; Astellas Pharma; GlaxoSmithKline Japan; Kyowa Hakko Kirin; Pfizer; Dainippon Sumitomo Pharma; Boehringer Ingelheim Japan; Astellas Foundation for Research on Metabolic Disorders; GlaxoSmithKline; FP Pharmaceutical Corporation; Bristol-Myers Squibb; Eli Lilly and Company; MSD K.K.; Asahi Kasei Pharma Corporation","keywords":"Venlafaxine; Placebo; Major depressive disorder; Medicine; Term (time); Randomized controlled trial; Immediate release; Anesthesia; Venlafaxine Hydrochloride; Internal medicine; Psychiatry; Pharmacology; Antidepressant; Anxiety; Physics; Alternative medicine; Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002722887,0.001079693,0.003636422,0.0003402859,0.0005161414,0.0005259223,0.0006614078,0.001263351,0.002171804],"category_scores_gemma":[0.001598905,0.0007152154,0.00139704,0.0002942746,0.001138511,0.0006427654,0.0003114921,0.001403032,0.0002872208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000480704,"about_ca_system_score_gemma":0.001383398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006170492,"about_ca_topic_score_gemma":0.001862917,"domain_scores_codex":[0.9987617,0.0006536422,0.0001576079,0.0002126227,0.0001068433,0.0001076901],"domain_scores_gemma":[0.9988524,0.000220634,0.0002929573,0.000127246,0.0001316269,0.0003752011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9515552,0.01862592,0.002355231,0.0009095601,0.001370636,0.00006707961,0.00009842252,0.0001673282,0.007618992,0.00006824834,0.0003089779,0.01685443],"study_design_scores_gemma":[0.8386265,0.1543284,0.005342464,0.00002410766,0.0006222613,0.00003546338,0.00002066648,0.0002005049,0.0003361818,0.00002880184,0.000419211,0.0000153974],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903134,0.003150419,0.0007251473,0.0001922867,0.0003470439,0.00460828,0.0002231473,0.00004113094,0.000399159],"genre_scores_gemma":[0.985898,0.002187183,0.002367215,0.0007168132,0.0004689135,0.006863268,0.000366924,0.000008264706,0.001123302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003636422,"threshold_uncertainty_score":0.01440018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05728496281993833,"score_gpt":0.4471914282007698,"score_spread":0.3899064653808315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}