{"id":"W2313586256","doi":"10.1038/mtm.2016.18","title":"Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses","year":2016,"lang":"en","type":"review","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada); Ottawa Hospital","funders":"","keywords":"Oncolytic virus; Computational biology; Biology; Virus; Biotechnology; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001026496,0.0006594311,0.0007856468,0.001510515,0.0001831441,0.001204022,0.0006192214,0.001037976,0.001423291],"category_scores_gemma":[0.0006570604,0.0003712127,0.0004749878,0.001099302,0.0004469864,0.001579486,0.0007547871,0.002091367,0.001549322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000692577,"about_ca_system_score_gemma":0.001055282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006815958,"about_ca_topic_score_gemma":0.0008898006,"domain_scores_codex":[0.9996969,0.00004317915,0.0000344119,0.00004542483,0.0001485894,0.000031581],"domain_scores_gemma":[0.9997804,0.00007918217,0.00003277501,0.000009909232,0.00007617402,0.00002166308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006404576,0.000100568,0.0002148035,0.01302214,0.00004794775,0.0002020353,0.0001370131,0.0006741133,0.02853141,0.006655443,0.01414829,0.9362021],"study_design_scores_gemma":[0.00002018747,0.0001713964,0.000545638,0.001804436,0.00005962631,0.001142935,0.00006397237,0.0002828581,0.009565854,0.002039298,0.9842781,0.00002577667],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008526476,0.994729,0.001819977,0.0003903514,0.0001952995,0.00002370058,0.00002782777,0.00002667011,0.001934483],"genre_scores_gemma":[0.002508453,0.9944927,0.001653872,0.0002395156,0.00008806934,0.00002238333,0.00006496633,0.000005751782,0.0009243387],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001510515,"threshold_uncertainty_score":0.005428672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2024582552555836,"score_gpt":0.5138634088228434,"score_spread":0.3114051535672598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}