{"id":"W2313586256","doi":"10.1038/mtm.2016.18","title":"Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses","year":2016,"lang":"en","type":"review","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada); Ottawa Hospital","funders":"","keywords":"Oncolytic virus; Computational biology; Biology; Virus; Biotechnology; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01493535,0.0008741159,0.002310044,0.0002421441,0.0003565735,0.00009440223,0.001334947,0.001089154,0.00009047044],"category_scores_gemma":[0.003059995,0.0005735223,0.001024286,0.0005632794,0.001056641,0.00002207035,0.0006058359,0.0008337572,0.00008729073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268979,"about_ca_system_score_gemma":0.002337382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000698556,"about_ca_topic_score_gemma":0.00001438633,"domain_scores_codex":[0.9839685,0.008688632,0.004163253,0.00188823,0.0006799158,0.0006114667],"domain_scores_gemma":[0.993494,0.001369446,0.002166142,0.002062732,0.0005662469,0.0003414001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006261769,0.0004653637,0.0002312689,0.0005867235,0.001441492,0.000004729999,0.0001166701,2.81381e-7,0.0309904,0.00001296307,0.00007183053,0.9654521],"study_design_scores_gemma":[0.001013082,0.001474434,0.000457851,0.001490923,0.0002819642,0.000008318796,0.00002679467,0.000001573801,0.04786993,0.0001476388,0.946499,0.000728522],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05936097,0.9210541,0.01402124,0.0003393966,0.001374166,0.003725912,0.00003049346,0.00005692502,0.00003680755],"genre_scores_gemma":[0.0001142472,0.9668679,0.02970215,0.001167775,0.0006929607,0.0005714098,0.0001573553,0.0001921269,0.0005340697],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9647236,"threshold_uncertainty_score":0.9996716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2024582552555836,"score_gpt":0.5138634088228434,"score_spread":0.3114051535672598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}