{"id":"W2313594417","doi":"10.1039/c6ob00471g","title":"Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines","year":2016,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Engineering and Physical Sciences Research Council; Cancer Research UK","keywords":"Chemistry; Heat shock protein; Apoptosis; Combinatorial chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007015524,0.0002970778,0.0004407984,0.00007214391,0.00007583803,0.00001629467,0.0001421689,0.0005369447,0.0001623966],"category_scores_gemma":[0.0009296071,0.000229072,0.000113761,0.0001526478,0.0008996034,0.0000192559,0.0002626512,0.0000568772,7.690411e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003782423,"about_ca_system_score_gemma":0.0002128039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001891892,"about_ca_topic_score_gemma":0.000001436318,"domain_scores_codex":[0.9978899,0.0001372878,0.0005595889,0.0006571959,0.0004292236,0.0003267505],"domain_scores_gemma":[0.9986261,0.00004374933,0.0002124981,0.0003810937,0.0005902192,0.0001463238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005317669,0.0001721995,0.0001178504,0.0005177577,0.0001190906,7.260688e-7,0.00002081114,5.354702e-7,0.9914312,0.000007902961,0.00001958048,0.007060553],"study_design_scores_gemma":[0.001815349,0.0002001072,0.000152196,0.0002728977,0.000127623,0.00003932519,0.000124249,0.000124879,0.9966879,0.0001698467,0.00002514248,0.0002604468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946434,0.001407811,0.002665618,0.0003526629,0.00001507496,0.0007695569,0.0001059468,0.00001249059,0.0000274276],"genre_scores_gemma":[0.9986927,0.0004920251,0.0004289969,0.00000498895,0.00009869072,0.0001464723,0.00008368153,0.00004009835,0.00001236625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006800106,"threshold_uncertainty_score":0.9341287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839116017959045,"score_gpt":0.2802799688280711,"score_spread":0.2618888086484806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}