{"id":"W2313634730","doi":"10.1158/1538-7445.am2011-4870","title":"Abstract 4870: High-throughput proteomics using stable isotope labelling with amino acids in cell culture (SILAC) reveals potential modulators of androgen-independent prostate cancers","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"LNCaP; Stable isotope labeling by amino acids in cell culture; Prostate cancer; Androgen; Androgen receptor; Cancer research; Biology; Androgen deprivation therapy; Internal medicine; Proteomics; Endocrinology; Chemistry; Cancer; Biochemistry; Medicine; Hormone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003449254,0.0005937254,0.0004159886,0.0004049757,0.0002899485,0.0004386933,0.0003220393,0.0003835458,0.002009442],"category_scores_gemma":[0.0001463044,0.0001614588,0.0003907074,0.0004403222,0.0002011714,0.0002465857,0.0001966411,0.0005556965,0.001230508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376199,"about_ca_system_score_gemma":0.000256408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005990535,"about_ca_topic_score_gemma":0.001007343,"domain_scores_codex":[0.9997584,0.00003359249,0.00001496648,0.00004169075,0.000105219,0.00004600973],"domain_scores_gemma":[0.9999005,0.00002195287,0.00001856745,0.000009215269,0.00002732785,0.00002251827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005521462,0.00001438773,0.00009079016,0.00003278289,0.000004535367,0.000023801,0.000005198683,0.00002676754,0.9989435,0.00002593013,0.00008978507,0.0006872384],"study_design_scores_gemma":[0.00001178245,0.0002292079,0.004496073,0.000007859153,0.00002221393,0.0002391094,0.00001580289,0.001420197,0.9895788,0.00004011547,0.003930542,0.000008311859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9413349,0.006733655,0.03983041,0.0005412287,0.0003039497,0.0001935958,0.004334203,0.0007879335,0.005940121],"genre_scores_gemma":[0.8944829,0.006744052,0.06721665,0.0005736458,0.000129881,0.0003200694,0.01331143,0.0002567598,0.01696463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002009442,"threshold_uncertainty_score":0.006722271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05101409669843671,"score_gpt":0.3363453826454649,"score_spread":0.2853312859470282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}