{"id":"W2313747654","doi":"10.1021/ol501898b","title":"Cu(I)-Catalyzed Macrocyclic Sonogashira-Type Cross-Coupling","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; Centre in Green Chemistry and Catalysis","keywords":"Sonogashira coupling; Chemistry; Catalysis; Combinatorial chemistry; Ring (chemistry); Coupling reaction; Coupling (piping); Stereochemistry; Organic chemistry; Palladium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993727,0.000577309,0.0004200824,0.0003355289,0.000200314,0.0002404025,0.0005079907,0.0002964392,0.001669117],"category_scores_gemma":[0.0001949491,0.0002130685,0.0002452511,0.0002048322,0.0002382103,0.0002471996,0.0003288861,0.0004350118,0.0006351068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003068144,"about_ca_system_score_gemma":0.0002960197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006888519,"about_ca_topic_score_gemma":0.001325559,"domain_scores_codex":[0.9998179,0.00003066012,0.00001447021,0.00004870604,0.00003658048,0.00005176855],"domain_scores_gemma":[0.9999108,0.00001333293,0.00001866116,0.00001419164,0.00001922305,0.0000236991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008797299,0.00002979383,0.0001458224,0.0001791197,0.00002946555,0.0003584914,0.00003473274,0.000330775,0.9835771,0.001299416,0.0004873374,0.01344012],"study_design_scores_gemma":[0.000008669964,0.0001906892,0.0003113458,0.000004244579,0.00001745297,0.0002805876,0.000007911894,0.000441111,0.9942473,0.00005330024,0.004425033,0.00001233297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7803908,0.01136556,0.176132,0.0003355311,0.0005723435,0.0007937739,0.0009142797,0.002248602,0.02724709],"genre_scores_gemma":[0.9469491,0.002980665,0.04312063,0.00007718975,0.00005658562,0.0002422255,0.0003973181,0.00007824471,0.006098036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001669117,"threshold_uncertainty_score":0.005583704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005977823108929792,"score_gpt":0.230160529166083,"score_spread":0.2241827060571532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}