{"id":"W2313896205","doi":"10.1021/cb300269g","title":"A Forward Chemical Screen Identifies Antibiotic Adjuvants in <i>Escherichia coli</i>","year":2012,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; McMaster University","keywords":"Novobiocin; Antibiotics; Escherichia coli; Bacteria; Microbiology; Biology; Gram-negative bacteria; Antimicrobial; Bacterial outer membrane; Intracellular; MreB; Membrane permeability; Biochemistry; Gene; Membrane; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002237099,0.0006196694,0.0005321752,0.0005166068,0.0001503144,0.0002885231,0.0002830197,0.0004538759,0.001193509],"category_scores_gemma":[0.0003474652,0.0002070505,0.0003641328,0.0003288905,0.0001881656,0.0001688542,0.0002420918,0.0003623606,0.0004445312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003100188,"about_ca_system_score_gemma":0.0004256756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009136773,"about_ca_topic_score_gemma":0.002860862,"domain_scores_codex":[0.9997312,0.00005024078,0.00001963352,0.00004223248,0.0001153306,0.00004118883],"domain_scores_gemma":[0.9997805,0.00005868712,0.00004369949,0.00001494068,0.00005695522,0.00004517705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001199094,0.0001145271,0.000304236,0.00007922308,0.00001083517,0.00006781345,0.00000586333,0.0002785886,0.9941959,0.00004855495,0.0000676972,0.00470672],"study_design_scores_gemma":[0.00003748812,0.003020467,0.001881526,0.00001467183,0.00004644386,0.0002922209,0.00001241405,0.0004811565,0.99185,0.00002404969,0.002329596,0.000009898441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817146,0.005287948,0.005687211,0.0003437455,0.00005809458,0.000444588,0.001376862,0.0002489387,0.004838104],"genre_scores_gemma":[0.9669062,0.005815856,0.01909513,0.0002798134,0.00002676947,0.0001519736,0.002098648,0.00005883942,0.005566857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193509,"threshold_uncertainty_score":0.003992736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113940836614101,"score_gpt":0.2618819213964659,"score_spread":0.2507425130303249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}