{"id":"W2313896205","doi":"10.1021/cb300269g","title":"A Forward Chemical Screen Identifies Antibiotic Adjuvants in <i>Escherichia coli</i>","year":2012,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; McMaster University","keywords":"Novobiocin; Antibiotics; Escherichia coli; Bacteria; Microbiology; Biology; Gram-negative bacteria; Antimicrobial; Bacterial outer membrane; Intracellular; MreB; Membrane permeability; Biochemistry; Gene; Membrane; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002856261,0.0003039307,0.0004148141,0.0000521424,0.00003389766,0.00002023263,0.0004661965,0.0006248438,0.00004118554],"category_scores_gemma":[0.0003792527,0.0002839642,0.0001221185,0.0001883407,0.0004051427,0.00001448161,0.0003525312,0.0002453904,0.00009098883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004013646,"about_ca_system_score_gemma":0.00004950142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002705838,"about_ca_topic_score_gemma":0.000009466486,"domain_scores_codex":[0.9979363,0.00009318158,0.0004583622,0.0005488651,0.0001078305,0.0008554385],"domain_scores_gemma":[0.9990647,0.00005154121,0.0001277881,0.0005025709,0.00005479993,0.0001985948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001547897,0.0001395949,0.1293215,0.00002036495,0.00004000491,0.000002148162,0.00002419269,1.187359e-7,0.8681341,0.0001746144,0.001524298,0.000464215],"study_design_scores_gemma":[0.0007016704,0.00005927024,0.01316952,0.00002691812,0.00002050813,0.00001590755,0.00004289654,0.000003691245,0.9787429,0.0001482553,0.006709959,0.0003584754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967147,0.00102376,0.0001127996,0.000142008,0.0003437863,0.0002191267,0.00004220515,0.00002941375,0.001372224],"genre_scores_gemma":[0.9965954,0.000181616,0.00139981,0.0006140637,0.0005800124,0.000008606853,0.0004289467,0.00003947371,0.0001520122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.116152,"threshold_uncertainty_score":0.9999613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113940836614101,"score_gpt":0.2618819213964659,"score_spread":0.2507425130303249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}