{"id":"W2313936515","doi":"10.1158/1538-7445.am2011-lb-33","title":"Abstract LB-33: Pre-clinical evaluation of AB-16B5, a monoclonal antibody specific for tumor-associated sCLU, demonstrates therapeutic potential as an inhibitor of EMT in prostate, pancreatic and lung cancer","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alethia Biotherapeutics (Canada)","funders":"","keywords":"DU145; Cancer research; Pancreatic cancer; Prostate cancer; Medicine; Cancer; Vimentin; In vivo; Gemcitabine; Monoclonal antibody; Prostate; Clusterin; Docetaxel; Apoptosis; Epithelial–mesenchymal transition; Immunohistochemistry; Cancer cell; Antibody; Pathology; Internal medicine; Immunology; Metastasis; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003664837,0.000167455,0.0005757599,0.0002951649,0.00006278708,0.00001518979,0.0001535777,0.0001450417,0.0007785875],"category_scores_gemma":[0.0004039831,0.000151648,0.00009254117,0.0003491977,0.000618909,0.0001259951,0.00007522055,0.0004030178,0.000001458202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002879886,"about_ca_system_score_gemma":0.001622863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001951095,"about_ca_topic_score_gemma":0.0006151947,"domain_scores_codex":[0.9968912,0.000521348,0.0007791788,0.0005031633,0.0008295253,0.0004755803],"domain_scores_gemma":[0.9977836,0.0003346058,0.0002502323,0.0003190617,0.001113476,0.0001989947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007491686,0.001287802,0.7560937,0.0008329164,0.0002648347,0.00005714456,0.001457682,0.00004730443,0.2228706,0.00002000182,0.0003046412,0.009271683],"study_design_scores_gemma":[0.005163958,0.001080633,0.9706848,0.0008059467,0.0002434478,0.00001310435,0.0003925043,0.00553376,0.01515852,0.0007828056,0.000007179943,0.0001333466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991007,0.005437767,0.000006410439,0.00007623764,0.000149308,0.002870568,0.000237054,0.00001434232,0.000201261],"genre_scores_gemma":[0.9977538,0.001011773,0.0001294374,0.00002417313,0.0001572453,0.0007446615,0.00007595502,0.0000389731,0.00006398322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2145911,"threshold_uncertainty_score":0.8524987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1963807648930076,"score_gpt":0.5188798082866372,"score_spread":0.3224990433936296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}