{"id":"W2313936515","doi":"10.1158/1538-7445.am2011-lb-33","title":"Abstract LB-33: Pre-clinical evaluation of AB-16B5, a monoclonal antibody specific for tumor-associated sCLU, demonstrates therapeutic potential as an inhibitor of EMT in prostate, pancreatic and lung cancer","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alethia Biotherapeutics (Canada)","funders":"","keywords":"DU145; Cancer research; Pancreatic cancer; Prostate cancer; Medicine; Cancer; Vimentin; In vivo; Gemcitabine; Monoclonal antibody; Prostate; Clusterin; Docetaxel; Apoptosis; Epithelial–mesenchymal transition; Immunohistochemistry; Cancer cell; Antibody; Pathology; Internal medicine; Immunology; Metastasis; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005082841,0.0007029176,0.0005740988,0.0003379936,0.0002684987,0.0005044434,0.0004789109,0.0005843409,0.002787582],"category_scores_gemma":[0.0002266957,0.0002243317,0.0004224088,0.0002134579,0.000361108,0.0002872818,0.0001864386,0.001680122,0.0009485883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005567101,"about_ca_system_score_gemma":0.0009040366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001683679,"about_ca_topic_score_gemma":0.003101917,"domain_scores_codex":[0.999782,0.00005321968,0.00001195555,0.00002593181,0.00004800131,0.0000789399],"domain_scores_gemma":[0.9998203,0.00001496466,0.00002442261,0.00001184011,0.00003334255,0.00009516777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0101678,0.01233824,0.001644084,0.0003066364,0.0001101491,0.0003362426,0.00009162293,0.000780345,0.9352115,0.000269797,0.00256126,0.03618223],"study_design_scores_gemma":[0.004610279,0.1917419,0.01772941,0.00005791493,0.0003468774,0.001348122,0.000111558,0.003047252,0.7576143,0.0001041117,0.02325539,0.00003291696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885207,0.004706966,0.001352017,0.0004204443,0.0001393623,0.0006535716,0.0006756633,0.0002112135,0.003319924],"genre_scores_gemma":[0.9896991,0.001808241,0.001326942,0.000217766,0.00003897667,0.0002771405,0.002217997,0.00002516134,0.004388706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002787582,"threshold_uncertainty_score":0.009325445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1963807648930076,"score_gpt":0.5188798082866372,"score_spread":0.3224990433936296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}