{"id":"W2313994511","doi":"10.1021/jp1035597","title":"Kinetics and Mechanism of<i>S</i>-Nitrosothiol Acid-Catalyzed Hydrolysis: Sulfur Activation Promotes Facile NO<sup>+</sup>Release","year":2011,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); Concordia University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Protonation; Nitroso; Hydrolysis; Nucleophile; Medicinal chemistry; Sulfur; Catalysis; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886729,0.0003885494,0.0002122113,0.0000612085,0.00006989036,0.0001577625,0.0002911829,0.0003218447,0.0009250508],"category_scores_gemma":[0.0001890792,0.0001082569,0.0001828372,0.00005435977,0.0002425654,0.0002248104,0.0001463608,0.0002769822,0.0003821677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783853,"about_ca_system_score_gemma":0.0001372304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143786,"about_ca_topic_score_gemma":0.001166357,"domain_scores_codex":[0.9998931,0.00001577516,0.00000632384,0.00002875284,0.00003228696,0.0000237197],"domain_scores_gemma":[0.9999274,0.00001716239,0.00002370971,0.00000578027,0.00001645456,0.000009534272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001156853,0.000009616771,0.0004064236,0.00007688807,0.00000891552,0.00003494831,0.00002277735,0.0003570051,0.9972649,0.0001324764,0.00004006858,0.001530416],"study_design_scores_gemma":[0.000004888131,0.0001101141,0.001412183,0.000003397716,0.000006822578,0.00005541269,0.00001888646,0.002349492,0.9954691,0.00005133127,0.0005136278,0.00000477162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906688,0.001383012,0.005781637,0.00006906083,0.0000167102,0.00004663149,0.0002220539,0.0001020922,0.00171001],"genre_scores_gemma":[0.9975925,0.0004245327,0.001164613,0.00001566827,0.000002308902,0.00001348903,0.0001056416,0.000009889482,0.000671434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143786,"threshold_uncertainty_score":0.003094673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319289706064959,"score_gpt":0.2252199474563205,"score_spread":0.2120270503956709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}