{"id":"W2313995036","doi":"10.1021/es503306g","title":"Combined C and Cl Isotope Effects Indicate Differences between Corrinoids and Enzyme (<i>Sulfurospirillum multivorans</i> PceA) in Reductive Dehalogenation of Tetrachloroethene, But Not Trichloroethene","year":2014,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Deutsche Forschungsgemeinschaft","keywords":"Corrinoid; Halogenation; Dehalogenase; Chemistry; Kinetic isotope effect; Cofactor; Isotopomers; Medicinal chemistry; Stereochemistry; Organic chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646434,0.0003942367,0.0002538493,0.000238448,0.0001453817,0.0003708047,0.0002920406,0.0002860252,0.000507503],"category_scores_gemma":[0.0002326433,0.0002093503,0.0002452738,0.0002114309,0.0002657533,0.0001960258,0.0002759042,0.000330312,0.000138684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004677282,"about_ca_system_score_gemma":0.0002249811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007361368,"about_ca_topic_score_gemma":0.008261551,"domain_scores_codex":[0.9997568,0.00002269733,0.00001855979,0.00008123654,0.00007009723,0.00005060937],"domain_scores_gemma":[0.9998413,0.00002770402,0.00003867689,0.00001941507,0.00003975163,0.00003305576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003445574,0.000002284806,0.0003346963,0.000005835911,0.000002520132,0.000008933094,0.000007471293,0.00001476062,0.9993499,0.000009598282,0.000002454369,0.0002270551],"study_design_scores_gemma":[0.00000233862,0.00005960443,0.01083291,0.000001575072,0.000009750888,0.00006014603,0.00003790177,0.0003388253,0.9883842,0.00001592827,0.000252918,0.000003871525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997745,0.0003111799,0.001205679,0.00002379971,0.000003807696,0.000006501697,0.0001815257,0.00003764166,0.0004848563],"genre_scores_gemma":[0.9981913,0.0000964062,0.0006478415,0.00001918,0.000001444598,0.000006302273,0.0003197604,0.00001427496,0.0007034979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007361368,"threshold_uncertainty_score":0.01463705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004403699971632581,"score_gpt":0.2040142230082689,"score_spread":0.1996105230366363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}