{"id":"W2313995036","doi":"10.1021/es503306g","title":"Combined C and Cl Isotope Effects Indicate Differences between Corrinoids and Enzyme (<i>Sulfurospirillum multivorans</i> PceA) in Reductive Dehalogenation of Tetrachloroethene, But Not Trichloroethene","year":2014,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Deutsche Forschungsgemeinschaft","keywords":"Corrinoid; Halogenation; Dehalogenase; Chemistry; Kinetic isotope effect; Cofactor; Isotopomers; Medicinal chemistry; Stereochemistry; Organic chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.000374553,0.000177339,0.0002644072,0.0003121299,0.0001185694,0.0000114751,0.0003144843,0.000207322,0.000002515388],"category_scores_gemma":[0.0001502948,0.0001619495,0.00002495301,0.0003174245,0.002746218,0.00002095422,0.0002990318,0.0001351276,0.00000151845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001849716,"about_ca_system_score_gemma":0.00001952674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003868142,"about_ca_topic_score_gemma":0.00001007441,"domain_scores_codex":[0.9986534,0.00006203567,0.000230174,0.0005559864,0.0001891455,0.0003092724],"domain_scores_gemma":[0.9994879,0.00003447789,0.0001374503,0.0002536054,0.000007914182,0.00007861859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003056346,0.0000600051,0.2907081,0.000006968338,0.000005129358,5.27899e-7,0.00006056449,0.000003059159,0.693861,0.0001151372,8.061854e-7,0.01514809],"study_design_scores_gemma":[0.0007036222,0.0003673191,0.4707987,0.000004888423,0.00001052206,0.000002589019,0.0001370202,0.00003453342,0.5273631,0.0003940843,0.00007375034,0.0001099551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979638,0.000563149,0.0008670737,0.0001370821,0.00006357538,0.0002980219,0.00001955029,0.00001417112,0.00007359793],"genre_scores_gemma":[0.9989178,0.0003709899,0.0005541346,0.0000606055,0.00001989327,0.00003085152,0.00001229194,0.00001007701,0.00002331004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1800905,"threshold_uncertainty_score":0.9999678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004403699971632581,"score_gpt":0.2040142230082689,"score_spread":0.1996105230366363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}