{"id":"W2314078457","doi":"10.1016/j.freeradbiomed.2014.10.790","title":"Inflammation-Enhanced Drug-Induced Liver Injury","year":2014,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Superoxide; Oxidative stress; Superoxide dismutase; Reactive oxygen species; Myeloperoxidase; NADPH oxidase; Biochemistry; Pharmacology; Inflammation; Spin trapping; Horseradish peroxidase; Radical; Immunology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002592163,0.0006032838,0.0003558677,0.0003987149,0.0002245214,0.0003059618,0.0001523684,0.0003278436,0.003305274],"category_scores_gemma":[0.0001428777,0.0001756273,0.0004249433,0.0002303274,0.0002663984,0.0005091007,0.0002455916,0.0006734282,0.0004885508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774294,"about_ca_system_score_gemma":0.0002944152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003365775,"about_ca_topic_score_gemma":0.0005559442,"domain_scores_codex":[0.9998356,0.00004090844,0.00001649695,0.00002105601,0.00003213658,0.00005382315],"domain_scores_gemma":[0.9998945,0.00001073433,0.00003362011,0.00001316556,0.00001730376,0.00003063935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003483123,0.0002897319,0.000544346,0.0001819836,0.00002436484,0.0002977769,0.00003841717,0.0001106811,0.99111,0.0003363137,0.00008827378,0.003494957],"study_design_scores_gemma":[0.0000613257,0.002170457,0.004987135,0.00001300855,0.00005336993,0.0003476081,0.0000407785,0.0005572243,0.990446,0.0001296143,0.001186404,0.000007230996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896595,0.003936364,0.003345592,0.0001974695,0.0001416284,0.00008327355,0.0002674624,0.0000770574,0.002291799],"genre_scores_gemma":[0.9953473,0.001264081,0.0008743482,0.00007028459,0.00002732627,0.0000241437,0.0001824665,0.000005817611,0.002204292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003305274,"threshold_uncertainty_score":0.01105726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06893965513377406,"score_gpt":0.4068226235962304,"score_spread":0.3378829684624564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}