{"id":"W2314112749","doi":"10.1021/acs.biochem.5b00217","title":"Impact of Amyloid Precursor Protein Hydrophilic Transmembrane Residues on Amyloid-Beta Generation","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Deutsche Forschungsgemeinschaft; Alzheimer Forschung Initiative; Canada Foundation for Innovation; Canada Research Chairs; Canadian Institutes of Health Research; Alzheimer Society","keywords":"Threonine; Transmembrane protein; Transmembrane domain; Amyloid precursor protein; Peptide sequence; Aspartic acid; Chemistry; Biochemistry; Amyloid precursor protein secretase; Amino acid; Residue (chemistry); P3 peptide; Serine; Alzheimer's disease; Phosphorylation; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791586,0.000354555,0.0001958205,0.0001248352,0.000108783,0.0002618264,0.0001264326,0.0002278434,0.0009088204],"category_scores_gemma":[0.000299883,0.0001061477,0.0002168376,0.0001220356,0.0003122697,0.000173196,0.0001921537,0.0003285391,0.0002218733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001606769,"about_ca_system_score_gemma":0.0001608762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005491661,"about_ca_topic_score_gemma":0.0004346021,"domain_scores_codex":[0.9998567,0.00004593638,0.00001550806,0.00002165197,0.00003430006,0.00002582495],"domain_scores_gemma":[0.9996127,0.0001110528,0.0001440795,0.00002318052,0.00002771319,0.00008121695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003908935,0.00003945389,0.000859644,0.00002144398,0.00001151009,0.0002214923,0.00001724142,0.0001552636,0.9976084,0.00004130212,0.000009213622,0.0006240646],"study_design_scores_gemma":[0.00003433489,0.001170984,0.02874524,0.00001927909,0.00005707571,0.001037666,0.00008046372,0.001880845,0.9658632,0.00009372632,0.0009952004,0.00002198967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993212,0.0001708583,0.0002598642,0.00001190951,0.000002914485,0.000007408953,0.00005905212,0.000006963838,0.0001599113],"genre_scores_gemma":[0.9993277,0.0001211553,0.0002992936,0.00001444936,0.000001805502,0.000004247937,0.0000746329,0.000008677766,0.0001481058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009088204,"threshold_uncertainty_score":0.003040314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04483135042858304,"score_gpt":0.3302669260110689,"score_spread":0.2854355755824859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}