{"id":"W2314133868","doi":"10.2967/jnumed.115.161513","title":"Modulation of Abnormal Metabolic Brain Networks by Experimental Therapies in a Nonhuman Primate Model of Parkinson Disease: An Application to Human Retinal Pigment Epithelial Cell Implantation","year":2016,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Bayer HealthCare; TRIUMF","keywords":"MPTP; Parkinsonism; Dopaminergic; Primate; Parkinson's disease; Retinal; Neuroscience; Internal medicine; Pathology; Medicine; Endocrinology; Biology; Dopamine; Disease; Ophthalmology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003348246,0.0004563465,0.0002294542,0.0004228766,0.0002709324,0.0002944258,0.0002035752,0.0003351127,0.0005603192],"category_scores_gemma":[0.000341041,0.000154871,0.0002546801,0.0002206522,0.0004387636,0.0001863119,0.0002707196,0.0003674254,0.00007505994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004440188,"about_ca_system_score_gemma":0.0002778063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003530023,"about_ca_topic_score_gemma":0.006711978,"domain_scores_codex":[0.9998606,0.00004148567,0.000007513542,0.00004397777,0.00002877245,0.00001768808],"domain_scores_gemma":[0.9998147,0.00003556941,0.00006294767,0.00004022807,0.00002341389,0.00002322341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004595835,0.0001728124,0.002628547,0.00007374024,0.00005146676,0.0002101616,0.0001192511,0.000690891,0.9854643,0.0001357682,0.00008410484,0.00990949],"study_design_scores_gemma":[0.0001382326,0.01034963,0.149463,0.00003634542,0.0002613179,0.002053401,0.0003918875,0.01444003,0.817574,0.0005842382,0.004660743,0.00004726072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99168,0.0007731604,0.006500166,0.0001021802,0.0000111984,0.00008000077,0.0002105957,0.00007471791,0.0005679823],"genre_scores_gemma":[0.9869113,0.0009579369,0.01071472,0.0000580891,0.000006335515,0.0002443674,0.0003376921,0.00001652515,0.0007529926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003530023,"threshold_uncertainty_score":0.007018983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432052492958287,"score_gpt":0.2907660814389265,"score_spread":0.2764455565093436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}