{"id":"W2314151980","doi":"10.1038/srep22161","title":"Multimodal Image Analysis in Alzheimer’s Disease via Statistical Modelling of Non-local Intensity Correlations","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 Information and Communication Technologies; Engineering and Physical Sciences Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; University of Southern California; University College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University College London Hospitals NHS Foundation Trust; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Magnetic resonance imaging; Positron emission tomography; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Cerebral atrophy; Posterior cortical atrophy; Partial least squares regression; Fluorodeoxyglucose; Pathology; Disease; Artificial intelligence; Alzheimer's disease; Neuroscience; Computer science; Pattern recognition (psychology); Medicine; Psychology; Dementia; Radiology; Machine learning","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00334039,0.0007284415,0.0008954569,0.0008670568,0.0001995711,0.0009891655,0.000825278,0.0006722587,0.00072785],"category_scores_gemma":[0.005567593,0.0004978302,0.001378074,0.0007687932,0.000826236,0.0008734476,0.0008477907,0.001006074,0.0003088017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004881951,"about_ca_system_score_gemma":0.0005796562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004468832,"about_ca_topic_score_gemma":0.004346887,"domain_scores_codex":[0.9992009,0.000459255,0.00002583607,0.0001830526,0.00008281208,0.00004816586],"domain_scores_gemma":[0.9975945,0.001699463,0.0003874118,0.0001470905,0.0001161865,0.00005529463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0001322691,0.00008014044,0.007430871,0.00008246087,0.0002537219,0.0002804112,0.0001580843,0.9281386,0.003236707,0.00888327,0.0008531409,0.05047018],"study_design_scores_gemma":[0.000003614167,0.00002156318,0.001119175,0.00000334854,0.00001312802,0.00002948297,0.000005705502,0.9937331,0.0001510901,0.004799269,0.0001135365,0.000006990314],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1653358,0.001187414,0.8314401,0.0005890584,0.00002441472,0.00004613401,0.0002823292,0.0005116409,0.0005831951],"genre_scores_gemma":[0.9258155,0.0009075531,0.07014616,0.000126394,0.00009770374,0.0001254594,0.0004825069,0.0001185578,0.002180113],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004468832,"threshold_uncertainty_score":0.01766592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05819272015918527,"score_gpt":0.348394349798752,"score_spread":0.2902016296395667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}