{"id":"W2314152749","doi":"10.1021/bm501849p","title":"Release of Anti-inflammatory Peptides from Thermosensitive Nanoparticles with Degradable Cross-Links Suppresses Pro-inflammatory Cytokine Production","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; McMaster University","keywords":"Cystamine; Tumor necrosis factor alpha; Chemistry; Peptide; Cytokine; Nanoparticle; PEGylation; Drug delivery; Inflammation; Biophysics; Biochemistry; Materials science; Nanotechnology; Immunology; Medicine; Organic chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761164,0.0002758055,0.0002523157,0.00006220067,0.00008171988,0.00005240492,0.0002273058,0.0002214401,0.000007908006],"category_scores_gemma":[0.0001372662,0.0002231098,0.00008952829,0.000112319,0.0003969661,0.00002679862,0.0001157705,0.0001020387,0.0000208021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001965195,"about_ca_system_score_gemma":0.0002292452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001333632,"about_ca_topic_score_gemma":0.0001165603,"domain_scores_codex":[0.9984185,0.0001047738,0.0003485034,0.0005506708,0.0002684678,0.0003091601],"domain_scores_gemma":[0.9985687,0.00001396501,0.0002240788,0.0005293721,0.0005162385,0.0001476134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000713198,0.0001189206,0.02226909,0.00002967097,0.0001592858,0.00006339669,0.000200227,0.0001135171,0.9746446,0.00001752711,0.001206386,0.0004641676],"study_design_scores_gemma":[0.0006769003,0.0004899204,0.02170956,0.00007321407,0.0000477047,0.0000442509,0.0003742609,0.00002989085,0.9752793,0.00007672817,0.0008968097,0.0003014199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976529,0.001370006,0.0001164843,0.00007653249,0.0001503336,0.0002865541,0.00009928423,0.0000414925,0.0002064391],"genre_scores_gemma":[0.9983729,0.00009540303,0.0007701516,0.00004907019,0.0002352614,0.0000303388,0.0001851404,0.00004328725,0.0002185076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274603,"threshold_uncertainty_score":0.9098153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672674177402593,"score_gpt":0.247744987698209,"score_spread":0.2310182459241831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}