{"id":"W2314154236","doi":"10.1021/tx500108u","title":"IgG<sub>3</sub> Is the Dominant Subtype of Anti-isoniazid Antibodies in Patients with Isoniazid-Induced Liver Failure","year":2014,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Isoniazid; Antibody; Liver injury; Medicine; Isotype; Immunology; Immune system; Pharmacology; Pathology; Tuberculosis; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003233018,0.000591272,0.0006296869,0.0009774612,0.0009251768,0.0004372719,0.0003155235,0.0006357142,0.001754199],"category_scores_gemma":[0.001404393,0.0003031766,0.0003040092,0.000711488,0.0004844537,0.0005477677,0.0003178144,0.0006662151,0.0003546535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003488064,"about_ca_system_score_gemma":0.00033827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001827783,"about_ca_topic_score_gemma":0.001556999,"domain_scores_codex":[0.99972,0.00004579373,0.00004732341,0.00005010892,0.00005018697,0.00008654098],"domain_scores_gemma":[0.9993076,0.000161619,0.0002490272,0.00004137053,0.00009269358,0.000147661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004089697,0.00007738908,0.9460936,0.00004293047,0.00002946706,0.04052703,0.0002396676,0.00005859595,0.004212464,0.00006457977,0.0003152358,0.007930024],"study_design_scores_gemma":[0.00004982911,0.0005033893,0.8448674,0.00003757845,0.00009308432,0.1506591,0.0005051256,0.0004725204,0.00178327,0.0001576974,0.0008521086,0.00001881355],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962223,0.0008359469,0.0002380144,0.0002192984,0.00002322868,0.00001962321,0.00003094333,0.00002305561,0.002387556],"genre_scores_gemma":[0.9995023,0.0001531991,0.00007260688,0.0001050409,0.00004298759,0.000002219864,0.00002054718,0.000002074796,0.000099014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001827783,"threshold_uncertainty_score":0.005868375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176858568378711,"score_gpt":0.4156251298697464,"score_spread":0.2979392730318753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}