{"id":"W2314170505","doi":"10.1074/mcp.m115.057257","title":"Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells","year":2016,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"MCF-7; Estrogen receptor alpha; Second messenger system; Estrogen receptor; Cancer research; Alpha (finance); Breast cancer; Signal transduction; Primary (astronomy); Messenger RNA; Estrogen receptor beta; Estrogen; Dynamics (music); Cancer; Biology; Cell biology; Chemistry; Endocrinology; Human breast; Medicine; Gene; Genetics; Psychology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145835,0.0002424755,0.0002935684,0.0003791132,0.0002086128,0.0002604942,0.0001432041,0.0001895086,0.0005838093],"category_scores_gemma":[0.00009075496,0.0001253924,0.0001751265,0.000545981,0.000120921,0.0001677935,0.0001214008,0.0002691079,0.0004542709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003388147,"about_ca_system_score_gemma":0.0001491381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001518833,"about_ca_topic_score_gemma":0.001985231,"domain_scores_codex":[0.9999015,0.000007863686,0.000006050413,0.00002981971,0.0000360716,0.00001856789],"domain_scores_gemma":[0.9999433,0.00001180836,0.000009844417,0.000005179506,0.00001871047,0.00001115932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004118213,0.000005583669,0.0002273863,0.00001944954,0.000003437949,0.00002069767,0.00001551614,0.00003492923,0.9990274,0.00002312765,0.00004224076,0.000539028],"study_design_scores_gemma":[0.000009849482,0.000085009,0.03759861,0.000006688906,0.00002753933,0.0002423032,0.00008068518,0.002011408,0.9561924,0.00007993301,0.003653639,0.00001197234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798233,0.003425863,0.008915472,0.0001654244,0.00003316247,0.00002999169,0.005185781,0.0001944371,0.002226499],"genre_scores_gemma":[0.9614645,0.005078355,0.01641569,0.0001970354,0.00002982187,0.0001547512,0.01022866,0.0001132311,0.006318023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518833,"threshold_uncertainty_score":0.003019989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002521999971432624,"score_gpt":0.19256340667518,"score_spread":0.1900414067037474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}