{"id":"W2314306670","doi":"10.1021/bi2008273","title":"Enhanced Specificity of the Viral Suppressor of RNA Silencing Protein p19 toward Sequestering of Human MicroRNA-122","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Steacie Institute for Molecular Sciences","funders":"Canadian Institutes of Health Research","keywords":"Small interfering RNA; Gene silencing; Trans-acting siRNA; RNA-induced silencing complex; RNA; Argonaute; Cell biology; microRNA; Biology; Binding site; RNA silencing; Mutant; RNA-binding protein; Molecular biology; Chemistry; RNA interference; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001337819,0.0003168877,0.0001844881,0.0001178224,0.0001248298,0.0002262859,0.0002599556,0.0002466753,0.0008676974],"category_scores_gemma":[0.0001753818,0.0001342531,0.0001819312,0.00008356343,0.000211705,0.0001242923,0.0002003882,0.0002948469,0.00045795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000204598,"about_ca_system_score_gemma":0.0001444989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005158126,"about_ca_topic_score_gemma":0.0004250527,"domain_scores_codex":[0.9998486,0.00003838464,0.00001446977,0.00002896828,0.00004542176,0.00002413659],"domain_scores_gemma":[0.9998711,0.00004589234,0.00003306378,0.00001256047,0.00001156307,0.00002577499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004691184,0.00001171068,0.0000680028,0.000008015016,0.000002072874,0.00003106506,0.000003812962,0.00006274565,0.9994528,0.00003833931,0.000009665668,0.0002649019],"study_design_scores_gemma":[0.000008713163,0.0001012774,0.0008292822,0.000001341476,0.000004635508,0.0002177944,0.000004844914,0.001271205,0.9969541,0.00001718522,0.000586529,0.00000307462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968637,0.0002606245,0.002119641,0.0000434777,0.00001180282,0.00001663827,0.00007131407,0.00003955513,0.000573314],"genre_scores_gemma":[0.9972337,0.0001380044,0.00169677,0.00002735577,0.000004272573,0.00001066852,0.0002139005,0.00002381795,0.000651626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008676974,"threshold_uncertainty_score":0.002902746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02711403376477176,"score_gpt":0.2442861819000253,"score_spread":0.2171721481352535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}