{"id":"W2314306670","doi":"10.1021/bi2008273","title":"Enhanced Specificity of the Viral Suppressor of RNA Silencing Protein p19 toward Sequestering of Human MicroRNA-122","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Steacie Institute for Molecular Sciences","funders":"Canadian Institutes of Health Research","keywords":"Small interfering RNA; Gene silencing; Trans-acting siRNA; RNA-induced silencing complex; RNA; Argonaute; Cell biology; microRNA; Biology; Binding site; RNA silencing; Mutant; RNA-binding protein; Molecular biology; Chemistry; RNA interference; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009543882,0.0001447447,0.0002028287,0.00001679019,0.00002695194,0.000003483221,0.0004450267,0.0001594697,0.00004346269],"category_scores_gemma":[0.00003664881,0.0001206234,0.0001661218,0.0000502308,0.0001939703,0.000003867748,0.0002278078,0.00008307445,8.073803e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001117956,"about_ca_system_score_gemma":0.00006365563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009041513,"about_ca_topic_score_gemma":0.00000360082,"domain_scores_codex":[0.9990682,0.00002660066,0.0003729369,0.0002474388,0.0001224052,0.0001623911],"domain_scores_gemma":[0.9990061,0.000003064655,0.0003101382,0.000508541,0.0001386282,0.00003352848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008915382,0.0001138088,0.0002761123,0.000230553,0.00004344896,5.429409e-7,0.0002486978,8.845838e-7,0.9988152,0.000008690541,0.00005501754,0.0001178731],"study_design_scores_gemma":[0.0002914839,0.0001705362,0.0007878803,0.0001636875,0.00001557222,0.000002427151,0.0002267174,0.00000184449,0.9981767,0.00003106556,0.000008286022,0.0001237954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969864,0.0002195399,0.0001278182,0.000005765579,0.00005816945,0.0001361029,0.00004914648,0.000004225968,0.002412758],"genre_scores_gemma":[0.9992005,0.00001401876,0.0002565425,0.000009721363,0.00007559334,0.000009530909,0.00001513931,0.00001298271,0.0004059723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002214026,"threshold_uncertainty_score":0.491888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02711403376477176,"score_gpt":0.2442861819000253,"score_spread":0.2171721481352535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}