{"id":"W2314331884","doi":"10.1089/nat.2014.0496","title":"Arabinonucleic Acids: 2′-Stereoisomeric Modulators of siRNA Activity","year":2014,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Computational biology; Pharmacology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538906,0.0002215176,0.0002513109,0.00006085682,0.0000634391,0.00001947277,0.0003672529,0.0002051479,0.00004451707],"category_scores_gemma":[0.00001815857,0.0002058004,0.000166708,0.0001222691,0.0001487656,0.000009317093,0.0001118428,0.0001242952,0.00004781361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001329602,"about_ca_system_score_gemma":0.00003480569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001152281,"about_ca_topic_score_gemma":0.000006486969,"domain_scores_codex":[0.9988645,0.00009032837,0.0002390727,0.0003432209,0.0001779951,0.0002849109],"domain_scores_gemma":[0.9990045,0.00001228528,0.0001660895,0.0006403552,0.0001028642,0.00007386151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121039,0.0001022639,0.003201813,0.00001726826,0.0001195341,4.1262e-7,0.00007675315,0.00003743446,0.9490768,0.0001264127,0.0001204523,0.04700873],"study_design_scores_gemma":[0.0005466334,0.0008099315,0.01088298,0.00001752246,0.00005248267,0.000009115977,0.0000538754,0.001269577,0.963976,0.0003308,0.02174167,0.0003093737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931611,0.0003721873,0.003807288,0.00008942465,0.0002451866,0.0001128326,0.00001134606,0.00002340253,0.002177247],"genre_scores_gemma":[0.9981517,0.0002984544,0.000394349,0.0006766978,0.000174944,0.000006252876,0.00001477499,0.00004174045,0.0002410819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04669936,"threshold_uncertainty_score":0.8392297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355388655186207,"score_gpt":0.2416192802555684,"score_spread":0.2280653937037064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}