{"id":"W2314331884","doi":"10.1089/nat.2014.0496","title":"Arabinonucleic Acids: 2′-Stereoisomeric Modulators of siRNA Activity","year":2014,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Computational biology; Pharmacology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268899,0.0004251548,0.0002415734,0.0001315383,0.0001080685,0.0002914112,0.0001948611,0.0002097901,0.001121468],"category_scores_gemma":[0.0001956616,0.0001151356,0.0001679124,0.0000946138,0.0001548989,0.0001613463,0.0001004217,0.0002831274,0.0003220998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877324,"about_ca_system_score_gemma":0.0001571723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000449896,"about_ca_topic_score_gemma":0.001135055,"domain_scores_codex":[0.9998398,0.00005037151,0.00001450225,0.00003585427,0.00003601582,0.00002342559],"domain_scores_gemma":[0.9998949,0.00003053569,0.00002954708,0.00001327776,0.00001610346,0.00001568016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005905034,0.00001337337,0.0000712941,0.0000211227,0.000003021076,0.00001608774,0.0000091871,0.00008114724,0.9981511,0.00007697299,0.00001727295,0.001480349],"study_design_scores_gemma":[0.000005545631,0.0001928968,0.0003188536,0.000001214505,0.000006127949,0.00004409894,0.000005143776,0.0002734813,0.997766,0.00001125765,0.001372686,0.000002528777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840807,0.003225505,0.007217661,0.00006070404,0.00003933104,0.00008499938,0.0002412751,0.0001234386,0.004926455],"genre_scores_gemma":[0.9886979,0.001484441,0.006939302,0.00005414414,0.00001506874,0.00006445923,0.0002596897,0.00003047377,0.002454472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121468,"threshold_uncertainty_score":0.003751636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355388655186207,"score_gpt":0.2416192802555684,"score_spread":0.2280653937037064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}