{"id":"W2314427977","doi":"10.1016/j.joca.2016.03.016","title":"Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage","year":2016,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Shriners Hospitals for Children - Canada","funders":"Canadian Arthritis Network; National Science Council; McGill University","keywords":"Cathepsin; Type II collagen; Cartilage; Chemistry; Cleavage (geology); Cathepsin K; Molecular biology; Cathepsin D; In vitro; Collagen, type I, alpha 1; Cathepsin B; Biochemistry; Extracellular matrix; Biology; Anatomy; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005064708,0.0004358331,0.0003979757,0.000364701,0.0003262056,0.000679006,0.0002093281,0.0003342592,0.002209607],"category_scores_gemma":[0.0004313347,0.0003506751,0.0005361486,0.0002279787,0.0004251622,0.0004995186,0.000216334,0.000569005,0.0004612841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006447745,"about_ca_system_score_gemma":0.0006284731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003473239,"about_ca_topic_score_gemma":0.004071875,"domain_scores_codex":[0.9996257,0.00009607182,0.0000413764,0.00004642452,0.0000763054,0.0001142137],"domain_scores_gemma":[0.9997179,0.00008332745,0.00004131197,0.00003779974,0.00006088151,0.00005866163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001192667,0.00003504829,0.0004944043,0.00007942759,0.00001382616,0.0001095797,0.00005915992,0.00003826422,0.9967757,0.00005700526,0.0000354232,0.001109554],"study_design_scores_gemma":[0.00004444082,0.000518811,0.01169941,0.00001159957,0.00003126931,0.0005856396,0.0001626734,0.0004002305,0.9853322,0.000048192,0.001154589,0.0000110269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914752,0.00555178,0.001462819,0.00007275873,0.0000404467,0.00001621298,0.0002027543,0.00002102087,0.001157006],"genre_scores_gemma":[0.993771,0.00122585,0.0008996669,0.00003466635,0.00001406386,0.00001098076,0.0003203358,0.00001012834,0.003713385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003473239,"threshold_uncertainty_score":0.00739187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008921644082334756,"score_gpt":0.221051720135106,"score_spread":0.2121300760527713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}