{"id":"W2314427977","doi":"10.1016/j.joca.2016.03.016","title":"Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage","year":2016,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Shriners Hospitals for Children - Canada","funders":"Canadian Arthritis Network; National Science Council; McGill University","keywords":"Cathepsin; Type II collagen; Cartilage; Chemistry; Cleavage (geology); Cathepsin K; Molecular biology; Cathepsin D; In vitro; Collagen, type I, alpha 1; Cathepsin B; Biochemistry; Extracellular matrix; Biology; Anatomy; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002348191,0.0001800233,0.0004425462,0.0002549642,0.00003516606,0.00001469408,0.00003638558,0.0001323484,0.00006570982],"category_scores_gemma":[0.00005826212,0.0001482894,0.00004039536,0.0003017988,0.00009701922,0.0001823628,0.000054118,0.00006249151,0.000004583876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005799144,"about_ca_system_score_gemma":0.00005038312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007133692,"about_ca_topic_score_gemma":0.002085547,"domain_scores_codex":[0.9986832,0.00007202502,0.000405635,0.0003334382,0.0001808601,0.0003248538],"domain_scores_gemma":[0.9995242,0.00004485489,0.00006689567,0.0002005099,0.00004452217,0.0001189989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005540487,0.0001039042,0.02152442,0.00002844668,0.000001008201,0.0003207298,0.0007173661,1.210264e-7,0.9510968,0.00009457213,0.000008072671,0.02555057],"study_design_scores_gemma":[0.009577023,0.001970395,0.007268604,0.0006513178,0.00002477512,0.00006568001,0.0002968083,0.000002456885,0.9794104,0.000155217,0.0004012048,0.000176142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954743,0.002843168,0.000002004762,0.0002327265,0.00007294107,0.000581769,0.00003420802,0.0000156149,0.0007432909],"genre_scores_gemma":[0.9984975,0.0004244247,0.0001389065,0.00005098692,0.00002008116,0.00004805428,0.000008837233,0.00002207687,0.0007890775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02831363,"threshold_uncertainty_score":0.6047066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008921644082334756,"score_gpt":0.221051720135106,"score_spread":0.2121300760527713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}