{"id":"W2314476344","doi":"10.1021/ac5011316","title":"Assembly of Multiple DNA Components through Target Binding toward Homogeneous, Isothermally Amplified, and Specific Detection of Proteins","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Loop-mediated isothermal amplification; DNA; Fluorescence; Streptavidin; Detection limit; Biophysics; Target protein; Molecular beacon; Molecular biology; Computational biology; Oligonucleotide; Biochemistry; Chromatography; Gene; Biotin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606691,0.0001522818,0.000258989,0.00002067019,0.00003540558,0.000009426772,0.0001111715,0.0001751285,0.000002523685],"category_scores_gemma":[0.0001156584,0.0001377486,0.0001185877,0.00009723623,0.0001745432,0.000004761731,0.00008090176,0.00008956735,5.129349e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001005638,"about_ca_system_score_gemma":0.00001350311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001596876,"about_ca_topic_score_gemma":0.000002569078,"domain_scores_codex":[0.9990594,0.00002759222,0.0002903733,0.0003160968,0.0001436999,0.0001628822],"domain_scores_gemma":[0.999382,0.0000261747,0.0001634131,0.0002748736,0.0000979954,0.00005552503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006821602,0.0000749407,0.0011199,0.00007598155,0.00006356486,7.835698e-7,0.000009377668,0.000009266007,0.9978088,0.00002260325,0.00001985348,0.0007266697],"study_design_scores_gemma":[0.0002490725,0.0001017901,0.0004099943,0.00003184048,0.00003199387,0.00001129735,0.00002628743,0.0007768367,0.9962448,0.0001162712,0.00184752,0.0001522451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505599,0.00009591103,0.04844438,0.00003954597,0.000009267043,0.00007696304,0.00002087048,0.00001740496,0.0007357405],"genre_scores_gemma":[0.9923904,0.0001113512,0.007198023,0.00003212939,0.00006534172,0.000003068016,0.00006939537,0.00001644142,0.0001138372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04183049,"threshold_uncertainty_score":0.5617223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712562441928923,"score_gpt":0.2520926581778318,"score_spread":0.2349670337585426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}