{"id":"W2314476344","doi":"10.1021/ac5011316","title":"Assembly of Multiple DNA Components through Target Binding toward Homogeneous, Isothermally Amplified, and Specific Detection of Proteins","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Loop-mediated isothermal amplification; DNA; Fluorescence; Streptavidin; Detection limit; Biophysics; Target protein; Molecular beacon; Molecular biology; Computational biology; Oligonucleotide; Biochemistry; Chromatography; Gene; Biotin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000431541,0.0005293165,0.0003289965,0.0003993328,0.000243512,0.0005054344,0.0006358611,0.0005477591,0.0003951963],"category_scores_gemma":[0.0004326568,0.0005139482,0.0003471872,0.0002730226,0.000397102,0.0004011176,0.0004267343,0.0007450634,0.0006348783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004613652,"about_ca_system_score_gemma":0.0003849552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007145808,"about_ca_topic_score_gemma":0.001098991,"domain_scores_codex":[0.9993655,0.0000876007,0.00002834809,0.0001704003,0.0002848673,0.00006333642],"domain_scores_gemma":[0.9997814,0.00004936981,0.00005904799,0.00002403304,0.0000590503,0.0000271466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001362184,0.00001950005,0.0000782401,0.00003012707,0.000003374073,0.00002734343,0.00003032288,0.0002216459,0.9962385,0.000270061,0.00003198595,0.003035306],"study_design_scores_gemma":[0.00000249946,0.00005288328,0.000147599,0.000001349201,0.000003637237,0.00004974433,0.00000499221,0.002009291,0.9969028,0.00004475985,0.0007765215,0.00000392331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4867053,0.002392788,0.5060823,0.0002342362,0.00006961663,0.0003025031,0.0001499219,0.001112147,0.002951253],"genre_scores_gemma":[0.7653302,0.00102925,0.2273434,0.0001891964,0.0000383244,0.0002397257,0.0003208842,0.0001106251,0.00539856],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.0007145808,"threshold_uncertainty_score":0.003347516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712562441928923,"score_gpt":0.2520926581778318,"score_spread":0.2349670337585426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}