{"id":"W2314619822","doi":"10.2174/1566523043346516","title":"Getting to the Heart of the Matter: Exploring Opportunities for Gene Therapy Treatment of Dystrophic Cardiomyopathy","year":2004,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"","keywords":"Cardiomyopathy; Muscular dystrophy; Genetic enhancement; Medicine; Duchenne muscular dystrophy; Bioinformatics; Disease; Skeletal muscle; Heart disease; Modalities; Cardiology; Heart failure; Gene; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173092,0.0004047295,0.0008700121,0.00005767896,0.0001388032,0.000009588567,0.0004620196,0.000135199,0.000009946198],"category_scores_gemma":[0.000007196968,0.0002186467,0.001013971,0.0001010233,0.0001262218,0.000003041198,0.00006869665,0.00007852185,0.000002161809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000314448,"about_ca_system_score_gemma":0.0003133167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001278787,"about_ca_topic_score_gemma":0.000001386094,"domain_scores_codex":[0.9985,0.0002226157,0.0004807874,0.0003892774,0.0001234326,0.0002838678],"domain_scores_gemma":[0.9986448,0.00003417976,0.0003245631,0.0008604085,0.00008376555,0.00005227401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000151131,0.0002069585,0.00002666784,0.001040748,0.0005245539,2.070135e-7,0.0002477876,0.0001084154,0.01288339,0.00001501195,0.0002910041,0.9845041],"study_design_scores_gemma":[0.0007135252,0.0008553625,0.00007648378,0.0006328514,0.0001182525,0.000006602423,0.00006264597,3.749345e-7,0.02562848,0.00004134584,0.9716062,0.0002578677],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07396419,0.9232363,0.0001122839,0.0001390372,0.0007034324,0.001623275,0.000204656,0.000005682768,0.0000111759],"genre_scores_gemma":[0.006371065,0.9914829,0.00006928689,0.00009013071,0.000498034,0.001186926,0.0002113893,0.00005623064,0.00003411102],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9842463,"threshold_uncertainty_score":0.8916153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2146530999943036,"score_gpt":0.3527091930057725,"score_spread":0.1380560930114689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}