{"id":"W2314705006","doi":"10.3389/fncel.2016.00074","title":"Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP−/− Mice","year":2016,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"Hippocampal formation; Hyperpolarization (physics); Chemistry; Neuroscience; HCN channel; Membrane potential; Apamin; Gating; Biophysics; Cell biology; Potassium channel; Biology; Ion channel; Receptor; Biochemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002079668,0.0002081138,0.0002218922,0.0001323915,0.00008561531,0.00004656183,0.0004841833,0.0001066024,0.000007592217],"category_scores_gemma":[0.001203934,0.0001760429,0.0000676553,0.0005690226,0.0001801734,0.00002532795,0.0002034164,0.0001328115,0.0000038158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008446025,"about_ca_system_score_gemma":0.0001399346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003383005,"about_ca_topic_score_gemma":0.00001655483,"domain_scores_codex":[0.9979641,0.0002176111,0.0003353061,0.0008654631,0.0001881574,0.0004293853],"domain_scores_gemma":[0.9992226,0.00002740578,0.00009389756,0.0004268642,0.00006303741,0.0001661901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001646461,0.0001000194,0.01563883,0.000006276139,0.000002304191,0.000003928342,0.00004799297,0.00005570781,0.966953,0.00000653712,0.000225419,0.01679537],"study_design_scores_gemma":[0.0008513988,0.00008417325,0.03492656,0.00006657565,0.000005690276,4.466804e-7,0.00003458571,0.0001354797,0.9551673,0.0004089943,0.008062582,0.0002562306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.881073,0.001881682,0.114632,0.0003640031,0.001439402,0.0005150842,0.00006428377,0.00001778734,0.00001277525],"genre_scores_gemma":[0.9979748,0.0004619447,0.00104535,0.0002950218,0.00007070595,0.00006065131,0.00003308721,0.00001721706,0.00004121249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1169018,"threshold_uncertainty_score":0.7178821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020621968563453,"score_gpt":0.2424923915975831,"score_spread":0.2322861719119486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}