{"id":"W2314710704","doi":"10.1038/srep23619","title":"Small molecule ice recrystallization inhibitors mitigate red blood cell lysis during freezing, transient warming and thawing","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Blood Services; Australian Government","keywords":"Cryoprotectant; Cryopreservation; Glycerol; Ice crystals; Recrystallization (geology); Dimethyl sulfoxide; Lysis; Ice formation; Chemistry; Vitrification; Andrology; Biochemistry; Biology; Cell biology; Embryo; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503727,0.0003450454,0.0002224728,0.0002127106,0.0001046107,0.0001820601,0.000203819,0.0001704807,0.001569415],"category_scores_gemma":[0.0001305807,0.00008434551,0.0002119193,0.00008242654,0.0001401871,0.0001363405,0.000113854,0.0005670433,0.000261751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139919,"about_ca_system_score_gemma":0.0001937652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004769678,"about_ca_topic_score_gemma":0.001193214,"domain_scores_codex":[0.9999357,0.000011524,0.000005571573,0.00001070662,0.00001716323,0.00001919673],"domain_scores_gemma":[0.999925,0.00001807392,0.00002367626,0.000005357326,0.0000120729,0.00001577495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002707426,0.0001360593,0.000136516,0.0001189558,0.00001628001,0.00002905443,0.00002167107,0.0002192609,0.9910644,0.00008265991,0.0001765944,0.007727697],"study_design_scores_gemma":[0.00004722086,0.00167851,0.00226732,0.00001331729,0.0000324088,0.00008605928,0.00001380202,0.0004546774,0.9927381,0.00001605335,0.002648226,0.00000425289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804302,0.009921654,0.005257086,0.0002084127,0.00006701183,0.0001694587,0.0004063812,0.0002305106,0.003309337],"genre_scores_gemma":[0.9816319,0.006591348,0.006647724,0.0001493054,0.0000421887,0.000101113,0.0006876786,0.0000237616,0.004124939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001569415,"threshold_uncertainty_score":0.005250216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104006190646761,"score_gpt":0.2148148771668493,"score_spread":0.2044142581021732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}