{"id":"W2314765906","doi":"10.1021/bm401532n","title":"Development and Characterization of Gene Silencing DNA Cages","year":2013,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gene silencing; RNA interference; Gene knockdown; Oligonucleotide; Gene; Biology; DNA; Gene expression; Small interfering RNA; Cell biology; Sense (electronics); RNA silencing; RNA; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115138,0.0002253169,0.0001625472,0.0001738784,0.0001160303,0.0001835809,0.0001886042,0.0002291639,0.0004507034],"category_scores_gemma":[0.000413551,0.0001233139,0.0001289571,0.0001292576,0.0001533222,0.0001400756,0.0001241136,0.0002391582,0.0003094159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109054,"about_ca_system_score_gemma":0.0002418147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000362467,"about_ca_topic_score_gemma":0.0004633653,"domain_scores_codex":[0.9998853,0.00001413692,0.00001113003,0.00002463177,0.00004920478,0.0000155289],"domain_scores_gemma":[0.999657,0.0000699392,0.00007248292,0.00004042061,0.00009625981,0.00006386465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006903758,0.000006413212,0.00006019415,0.00001318814,0.00000108456,0.00001890644,0.00001081429,0.0001814017,0.9987203,0.0001128808,0.00001410566,0.000853812],"study_design_scores_gemma":[0.000002241972,0.00007427818,0.000326605,0.000001359976,0.000001807732,0.00003872201,0.000005161044,0.0006862943,0.9976635,0.00001515144,0.001183175,0.000001710965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9208625,0.0007446316,0.0744125,0.0001224439,0.00003607965,0.0002790654,0.0008160882,0.000347487,0.002379141],"genre_scores_gemma":[0.9183921,0.0006646334,0.07578989,0.00004065925,0.000007096981,0.0002434923,0.001575623,0.000106283,0.003180198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004507034,"threshold_uncertainty_score":0.00153029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00765920862020137,"score_gpt":0.2286982017729685,"score_spread":0.2210389931527671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}