{"id":"W2314765906","doi":"10.1021/bm401532n","title":"Development and Characterization of Gene Silencing DNA Cages","year":2013,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gene silencing; RNA interference; Gene knockdown; Oligonucleotide; Gene; Biology; DNA; Gene expression; Small interfering RNA; Cell biology; Sense (electronics); RNA silencing; RNA; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005329748,0.0001051323,0.0001067993,0.00004601152,0.00004923086,0.00001582089,0.00006116978,0.00007637458,0.000001911519],"category_scores_gemma":[0.00001645811,0.00009037765,0.00003048144,0.00006610741,0.00006915618,0.000004151859,0.00005084126,0.00001738833,0.000001780057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005337284,"about_ca_system_score_gemma":0.00001941761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001109402,"about_ca_topic_score_gemma":0.000004770916,"domain_scores_codex":[0.9994112,0.0000184015,0.0001764924,0.0002045398,0.00007201935,0.0001173681],"domain_scores_gemma":[0.9996486,0.000003103411,0.00009319216,0.0001397946,0.00007574593,0.0000395965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004029265,0.00001838471,0.000298658,0.00001145653,0.00002666136,9.367295e-7,0.00003876656,3.176594e-8,0.9837551,0.000009150111,0.00001822551,0.01581859],"study_design_scores_gemma":[0.0000742812,0.00004276399,0.01201234,0.0000138068,0.000008517686,0.00001066579,0.0000340836,0.000008834108,0.9867172,0.000008809851,0.0009501955,0.0001185331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974862,0.0001106838,0.002167068,0.00003637589,0.00001606537,0.0000901824,0.000007603574,0.0000195693,0.00006620125],"genre_scores_gemma":[0.9773532,0.0000772092,0.02223665,0.00005899443,0.00003065919,0.000008655829,0.0001436416,0.00001057204,0.00008046172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02013309,"threshold_uncertainty_score":0.3685493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00765920862020137,"score_gpt":0.2286982017729685,"score_spread":0.2210389931527671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}