{"id":"W2314791461","doi":"10.1124/mol.59.5.1196","title":"<i>Tripterygium wilfordii</i>Hook F Extract Suppresses Proinflammatory Cytokine-Induced Expression of Matrix Metalloproteinase Genes in Articular Chondrocytes by Inhibiting Activating Protein-1 and Nuclear Factor-κB Activities","year":2001,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Tripterygium wilfordii; Proinflammatory cytokine; p38 mitogen-activated protein kinases; Matrix metalloproteinase; Arthritis; Cytokine; Tumor necrosis factor alpha; Pharmacology; Chondrocyte; Tripterygium; Chemistry; Protein kinase A; Inflammation; Kinase; Medicine; Cancer research; Cartilage; Immunology; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001602662,0.0004187614,0.000676776,0.0003399824,0.0001094712,0.00003060597,0.000141815,0.0001944564,0.0001983213],"category_scores_gemma":[0.00008634337,0.0003772167,0.000151394,0.0002815538,0.0001336211,0.0003422564,0.0001986751,0.0004472295,0.000002881927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001825134,"about_ca_system_score_gemma":0.0001001639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004120127,"about_ca_topic_score_gemma":0.000001675815,"domain_scores_codex":[0.9976707,0.0002752467,0.0005615086,0.0005639419,0.0003968622,0.0005317827],"domain_scores_gemma":[0.9990219,0.00009628452,0.0003293354,0.0002499257,0.00008777114,0.0002147186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001027896,0.0004807998,0.0009324269,0.0003379261,0.0001623813,0.001781522,0.0002369229,0.00001009421,0.9917883,0.000009793085,0.0000745718,0.003157334],"study_design_scores_gemma":[0.003919286,0.0003971682,0.0004418167,0.0002802718,0.0001554106,0.0002288203,0.0002303644,0.0001461185,0.9927894,0.00002948942,0.001068583,0.0003132577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941203,0.003508345,0.0000670916,0.0002903189,0.00008214705,0.001641507,0.00001915789,0.0001100289,0.0001610895],"genre_scores_gemma":[0.9974982,0.00008978416,0.001733551,0.0001382373,0.00007465524,0.0002639324,0.00002580765,0.0000792488,0.00009664089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003418561,"threshold_uncertainty_score":0.999868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155537296867578,"score_gpt":0.2890578151118919,"score_spread":0.2775024421432161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}