{"id":"W2314794990","doi":"10.1002/jbmr.2851","title":"The Actin-Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro","year":2016,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Harvard School of Dental Medicine","keywords":"Podosome; Cofilin; Cortactin; Cell biology; Bone resorption; Chemistry; Actin; Cytoskeleton; Actin cytoskeleton; Biology; Biochemistry; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001039015,0.00008211262,0.0001763822,0.0002170832,0.00006367995,0.00005399271,0.00002868652,0.00006430742,9.032884e-7],"category_scores_gemma":[0.0005320022,0.00004848561,0.00001559292,0.00008431572,0.00007066117,0.00004411561,0.00006022382,0.0001608318,6.199431e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001766115,"about_ca_system_score_gemma":0.00004831261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004559073,"about_ca_topic_score_gemma":0.0007439654,"domain_scores_codex":[0.9990566,0.0001509219,0.000263005,0.0001685859,0.000146203,0.0002146465],"domain_scores_gemma":[0.9994787,0.0001416772,0.0001425629,0.00005717381,0.00009856468,0.00008133105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005598875,0.00003244683,0.01988837,0.00004485989,0.000006589093,0.00003283843,0.00006001439,3.040226e-7,0.9667807,0.000004013563,0.00004838529,0.007502637],"study_design_scores_gemma":[0.008910212,0.001259652,0.1381374,0.001130466,0.00001500067,0.0003057874,0.001856471,0.0001161899,0.8458745,0.00009847312,0.002073054,0.0002227725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962977,0.002523575,0.00000925607,0.0008739988,0.00001780157,0.0002572613,0.00001176339,6.635132e-7,0.000007956604],"genre_scores_gemma":[0.9978524,0.001564538,0.00007327992,0.00001233232,0.00007517528,0.00002138121,0.000001944357,0.000008872606,0.0003901012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1209061,"threshold_uncertainty_score":0.1977186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03522355829523403,"score_gpt":0.3244423914472944,"score_spread":0.2892188331520603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}