{"id":"W2314904660","doi":"10.1021/tx400098z","title":"12-OH-Nevirapine Sulfate, Formed in the Skin, Is Responsible for Nevirapine-Induced Skin Rash","year":2013,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Sulfotransferase; Chemistry; Covalent bond; Sulfation; Rash; Metabolite; Microsome; Biochemistry; Pharmacology; In vitro; Medicine; Organic chemistry; Dermatology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008765224,0.0004156417,0.0002609653,0.0002756192,0.0001493712,0.0001404232,0.0001420231,0.0002627937,0.001356443],"category_scores_gemma":[0.0001421488,0.0001519723,0.0002639888,0.0001126825,0.0001293521,0.00008395488,0.00009444127,0.0004066993,0.0003172822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228194,"about_ca_system_score_gemma":0.000140527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008775979,"about_ca_topic_score_gemma":0.0008892234,"domain_scores_codex":[0.9998622,0.00002191689,0.000009337437,0.00002340201,0.00006253236,0.00002063706],"domain_scores_gemma":[0.9999099,0.000009687183,0.00003676414,0.000006756683,0.00001625026,0.00002076451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009231127,0.00003222387,0.0009206477,0.00005352741,0.00001280121,0.0002243396,0.00000629137,0.00002963036,0.9939465,0.00003331012,0.00005111798,0.004597318],"study_design_scores_gemma":[0.00003325349,0.0007949671,0.05563041,0.00001714105,0.00005999499,0.00444281,0.00003904946,0.0006762373,0.9321639,0.0000886945,0.006045928,0.000007694847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98044,0.01067315,0.002997617,0.0001888672,0.00005344154,0.0000956025,0.0003108307,0.0002170238,0.00502357],"genre_scores_gemma":[0.9918241,0.003570319,0.001190424,0.00006341429,0.00002409783,0.00002138556,0.0002829739,0.00001366289,0.003009553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356443,"threshold_uncertainty_score":0.004537761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09797309403055085,"score_gpt":0.376483292130763,"score_spread":0.2785101981002122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}