{"id":"W2314911233","doi":"10.1016/j.neuroscience.2016.04.005","title":"Preferred recycling pathway by internalized PGE2 EP4 receptor following agonist stimulation in cultured dorsal root ganglion neurons contributes to enhanced EP4 receptor sensitivity","year":2016,"lang":"en","type":"article","venue":"Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dorsal root ganglion; Agonist; Prostaglandin E2 receptor; Receptor; Nociceptor; Chemistry; Cell biology; Internalization; Calcitonin gene-related peptide; Prostaglandin E2; Endosome; Stimulation; Pharmacology; Internal medicine; Endocrinology; Biology; Nociception; Neuropeptide; Biochemistry; Neuroscience; Spinal cord; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002543477,0.0002937972,0.0006272852,0.000280673,0.0003676574,0.0007239842,0.0004124162,0.0005554048,0.002314267],"category_scores_gemma":[0.00025778,0.0002339346,0.0006598054,0.000222678,0.0002671561,0.0006475041,0.0003556022,0.001135734,0.0005345601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005751937,"about_ca_system_score_gemma":0.0004320475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001771525,"about_ca_topic_score_gemma":0.002121527,"domain_scores_codex":[0.9996933,0.00003723764,0.00003307253,0.0000421893,0.0000661738,0.0001280536],"domain_scores_gemma":[0.99989,0.00002667218,0.00001304927,0.0000213599,0.00003111014,0.0000179161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002654715,0.00002160316,0.0002076077,0.00005077622,0.000006737898,0.0001709838,0.00003712544,0.00002723314,0.9982469,0.0001968168,0.00003209038,0.0007366041],"study_design_scores_gemma":[0.00002880951,0.0001659621,0.01316424,0.00001516856,0.00003861916,0.000440865,0.000214629,0.001312674,0.9835228,0.0001427826,0.0009436173,0.000009714595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951161,0.0008694231,0.00227837,0.0001026256,0.00003007732,0.00001598897,0.000227791,0.00002382118,0.001335729],"genre_scores_gemma":[0.9923217,0.0006102724,0.002060249,0.00007291008,0.00001070281,0.00004561404,0.0003026036,0.00001789994,0.004558271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002314267,"threshold_uncertainty_score":0.007741988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831396184506859,"score_gpt":0.2878974746362963,"score_spread":0.2695835127912277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}