{"id":"W2314927739","doi":"10.1056/nejm200009283431302","title":"Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer","year":2000,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":3010,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"","keywords":"Irinotecan; Medicine; Fluorouracil; Bolus (digestion); Colorectal cancer; Chemotherapy; Internal medicine; Gastroenterology; Surgery; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001254062,0.0004494963,0.001367637,0.0003438221,0.0002592984,0.0003402687,0.0004237332,0.000468619,0.002662165],"category_scores_gemma":[0.001015678,0.0001993469,0.0009577751,0.0004406012,0.0004710722,0.0002796796,0.0002421183,0.000901561,0.0003035042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007748544,"about_ca_system_score_gemma":0.001420129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007840097,"about_ca_topic_score_gemma":0.002465489,"domain_scores_codex":[0.9993885,0.0003509074,0.00004265366,0.00006853625,0.00008303183,0.00006633886],"domain_scores_gemma":[0.9994037,0.0001610545,0.0001178313,0.00002652726,0.00002177813,0.0002690904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8152265,0.008153515,0.01535602,0.001402187,0.002271681,0.0002573448,0.0000575568,0.002884654,0.017986,0.000349803,0.001622615,0.1344322],"study_design_scores_gemma":[0.3938846,0.5351316,0.05287946,0.0001470193,0.002285336,0.001270983,0.00004819025,0.002534063,0.005911075,0.0003695777,0.005509938,0.00002817111],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989169,0.007965272,0.0003365267,0.0003818478,0.0001253654,0.0007696021,0.000201664,0.00002357184,0.001027135],"genre_scores_gemma":[0.9944608,0.003011601,0.0008679578,0.0002293033,0.0002003975,0.000400499,0.0002731856,0.000003848573,0.0005524041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002662165,"threshold_uncertainty_score":0.008905768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03290594841131935,"score_gpt":0.3246259538774529,"score_spread":0.2917200054661335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}