{"id":"W2314929224","doi":"10.1021/cb500880f","title":"Biophysical and Biological Characterization of Hairpin and Molecular Beacon RNase H Active Antisense Oligonucleotides","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"Oligonucleotide; RNase P; RNA; Huntingtin; RNase H; Nucleic acid; Molecular beacon; Gene silencing; Cleavage (geology); Chemistry; Cell biology; Huntingtin Protein; Biology; Small hairpin RNA; Biophysics; Molecular biology; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074014,0.0001283577,0.000213765,0.00003258101,0.00002153188,0.000008409334,0.00008953312,0.0002250698,0.000001934242],"category_scores_gemma":[0.0002950447,0.0001038421,0.00003361945,0.00006019809,0.0004455018,0.000005185495,0.0002145984,0.00009561983,0.000001700528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006437971,"about_ca_system_score_gemma":0.00002843908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001491747,"about_ca_topic_score_gemma":5.108363e-7,"domain_scores_codex":[0.9991489,0.00007929156,0.0001600214,0.0003343701,0.0000537376,0.0002236813],"domain_scores_gemma":[0.9995065,0.00002138028,0.00006314518,0.0001487742,0.00008299749,0.0001772546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002590786,0.00004641144,0.002277172,0.000008432318,0.00003147577,0.000005058354,0.00001979092,7.846106e-8,0.9919104,0.0003354325,0.00002330039,0.005083382],"study_design_scores_gemma":[0.0005668424,0.0004463434,0.001915974,0.00000671051,0.000007096502,0.00002305603,0.00003040549,0.00004895201,0.9961819,0.0002228921,0.0004305349,0.0001192639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991261,0.0001795425,0.0001838796,0.0002766367,0.00002239415,0.0001151184,0.00003982336,0.000008824491,0.00004763735],"genre_scores_gemma":[0.9989461,0.000233845,0.0002652402,0.0001722694,0.00007016586,0.000007439512,0.0002782205,0.000009376052,0.00001731899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004964117,"threshold_uncertainty_score":0.4234559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656476291069164,"score_gpt":0.2690919333620329,"score_spread":0.2525271704513412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}