{"id":"W2314929224","doi":"10.1021/cb500880f","title":"Biophysical and Biological Characterization of Hairpin and Molecular Beacon RNase H Active Antisense Oligonucleotides","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"Oligonucleotide; RNase P; RNA; Huntingtin; RNase H; Nucleic acid; Molecular beacon; Gene silencing; Cleavage (geology); Chemistry; Cell biology; Huntingtin Protein; Biology; Small hairpin RNA; Biophysics; Molecular biology; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840783,0.0001437942,0.0001078442,0.00008540935,0.00008203534,0.0001367132,0.0001094693,0.0001699473,0.0003518518],"category_scores_gemma":[0.0003503294,0.00007235914,0.0001003772,0.00008615143,0.0001346784,0.000097133,0.00004540792,0.0002629799,0.0001289369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001604573,"about_ca_system_score_gemma":0.0001246909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003516675,"about_ca_topic_score_gemma":0.0004454511,"domain_scores_codex":[0.9999166,0.00001425448,0.00000656915,0.00001777365,0.00003099895,0.00001391808],"domain_scores_gemma":[0.999833,0.00004240395,0.00003976021,0.000009236995,0.00003977181,0.00003568306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008737026,0.000006117247,0.0000513796,0.000004182403,7.135112e-7,0.0000054725,0.000006351631,0.00005100515,0.9996244,0.00003753957,0.000006561421,0.0001975162],"study_design_scores_gemma":[0.000006580352,0.0001567737,0.001699784,0.00000149832,0.000004356858,0.00005295044,0.00001556931,0.001638497,0.9952326,0.00005299485,0.001134828,0.000003478294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888609,0.0004733332,0.009521356,0.00006665872,0.00002424343,0.00002630937,0.0001590194,0.00004328429,0.0008248006],"genre_scores_gemma":[0.9910296,0.000382383,0.006366429,0.0000650599,0.00001023578,0.00004299959,0.0003749915,0.00002134835,0.001706928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003518518,"threshold_uncertainty_score":0.001177073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656476291069164,"score_gpt":0.2690919333620329,"score_spread":0.2525271704513412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}