{"id":"W2314944728","doi":"10.1097/00002030-200203290-00019","title":"Delavirdine increases drug exposure of ritonavir-boosted protease inhibitors","year":2002,"lang":"en","type":"letter","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver","funders":"","keywords":"Saquinavir; Indinavir; Amprenavir; Ritonavir; Pharmacology; Nelfinavir; Lopinavir; Protease inhibitor (pharmacology); Efavirenz; Nevirapine; Protease; Medicine; Virology; Biology; Viral load; HIV-1 protease; Virus; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001679173,0.0006086978,0.001083132,0.0004662312,0.00007598478,0.00001883172,0.0001852093,0.0006238488,0.0008137143],"category_scores_gemma":[0.0001260658,0.000486616,0.0003829989,0.000403954,0.0001490237,0.00009113704,0.0001032481,0.001083584,0.0003405022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001740352,"about_ca_system_score_gemma":0.0002144858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002404489,"about_ca_topic_score_gemma":0.000003499119,"domain_scores_codex":[0.9971756,0.0001388351,0.0007627665,0.0005827227,0.0008548351,0.0004852548],"domain_scores_gemma":[0.998435,0.0001528818,0.0003174774,0.0007049058,0.0002069052,0.0001827996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008077933,0.0004695955,0.05301842,0.0005740186,0.0006371131,0.002397994,0.0002537152,2.004753e-7,0.0001200003,0.000004490353,0.93871,0.003733684],"study_design_scores_gemma":[0.004301557,0.0006129406,0.001978849,0.001887074,0.001459565,0.0002132895,0.00007213084,0.000006684077,0.009198051,0.00004144862,0.9795225,0.000705923],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.5200309,0.0064761,0.00001056043,0.4573428,0.0007592948,0.004761383,0.0003642607,0.0004934488,0.009761271],"genre_scores_gemma":[0.365808,0.0004634097,0.00540031,0.1538871,0.007864367,0.0009634345,0.007337077,0.000472662,0.4578036],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4480424,"threshold_uncertainty_score":0.9997585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377291006892546,"score_gpt":0.2370569993939234,"score_spread":0.2232840893249979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}