{"id":"W2314949866","doi":"10.1021/bi201019n","title":"Bacterial and Viral Sialidases: Contribution of the Conserved Active Site Glutamate to Catalysis","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Enzyme kinetics; Sialidase; Chemistry; Residue (chemistry); Biochemistry; Active site; Stereochemistry; Mutant; Enzyme; Neuraminidase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003721904,0.0003347914,0.0002971559,0.0001056754,0.0001290111,0.0004138819,0.0002947384,0.0003962812,0.0003846923],"category_scores_gemma":[0.0003499989,0.0001449458,0.0002674451,0.0001215923,0.0003951278,0.0002430384,0.0002308096,0.0003147745,0.0001851933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000470351,"about_ca_system_score_gemma":0.0004166079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009639757,"about_ca_topic_score_gemma":0.0009587844,"domain_scores_codex":[0.9997631,0.00004965936,0.00002112464,0.00003474355,0.0000785808,0.00005289878],"domain_scores_gemma":[0.9998983,0.00002655046,0.00001628947,0.00001477071,0.00001802813,0.00002604247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004921739,0.00004350379,0.002380668,0.00007682623,0.00003262538,0.000155387,0.00002892524,0.001214171,0.9903134,0.0007306783,0.00001747007,0.004514185],"study_design_scores_gemma":[0.00003188127,0.0002545762,0.003849311,0.000007569426,0.00003584269,0.0004390407,0.00005072192,0.003916326,0.9904926,0.0003717022,0.0005402964,0.000009945772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972778,0.0006136501,0.001615341,0.00004321955,0.000004684952,0.000007104104,0.00003000837,0.000008488338,0.0003998514],"genre_scores_gemma":[0.9985719,0.0002432624,0.000928722,0.00001169317,9.936801e-7,0.000003333686,0.0000530122,0.000005195818,0.0001819718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009639757,"threshold_uncertainty_score":0.003412664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143135098308831,"score_gpt":0.244044431582794,"score_spread":0.2326130805997056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}