{"id":"W2315031766","doi":"10.1021/bi1017842","title":"Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from <i>Borrelia burgdorferi</i>, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Fosfomycin; Active site; Chemistry; Enzyme kinetics; Borrelia burgdorferi; Stereochemistry; Protonation; Carboxylate; Biochemistry; Enzyme; Biology; Antibiotics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005791288,0.0003022386,0.0004213094,0.00004402003,0.000248726,0.00003327462,0.0003681765,0.0001357002,0.0001743074],"category_scores_gemma":[0.0007496029,0.0001834118,0.0002451847,0.0003235846,0.001198864,0.00008089511,0.0003656654,0.000370906,0.00002853837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001241418,"about_ca_system_score_gemma":0.0004811079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001116981,"about_ca_topic_score_gemma":0.00002986693,"domain_scores_codex":[0.9980758,0.00007626626,0.0003783358,0.0005427419,0.0004927695,0.0004340679],"domain_scores_gemma":[0.9974176,0.0003334437,0.0002215237,0.001323547,0.0002629003,0.0004409353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00293724,0.0002430465,0.001345032,0.0000934901,0.0002596307,0.00003783251,0.001077212,8.718686e-8,0.9915013,0.000298641,0.0007954347,0.001411051],"study_design_scores_gemma":[0.00198861,0.00005116514,0.2087525,0.0002173577,0.0003341182,0.00003273602,0.001801769,0.00007546016,0.7851509,0.0004021848,0.001005276,0.0001878568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841689,0.002112909,0.00001736341,0.001595208,0.0000559634,0.0007935551,0.002030175,0.00004597202,0.009179888],"genre_scores_gemma":[0.9982188,0.0001808644,0.00008404025,0.0002401107,0.0001765622,0.0000978423,0.0001488582,0.00003574336,0.0008172301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2074075,"threshold_uncertainty_score":0.7479315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171137393635429,"score_gpt":0.2297622034220056,"score_spread":0.2180508294856513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}