{"id":"W2315031766","doi":"10.1021/bi1017842","title":"Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from <i>Borrelia burgdorferi</i>, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Fosfomycin; Active site; Chemistry; Enzyme kinetics; Borrelia burgdorferi; Stereochemistry; Protonation; Carboxylate; Biochemistry; Enzyme; Biology; Antibiotics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001937768,0.0004994136,0.0003763052,0.0001081805,0.00008132917,0.0003346239,0.0003268578,0.0003224402,0.00064005],"category_scores_gemma":[0.000283796,0.0001232257,0.0002185109,0.0002838127,0.0002313985,0.0002654385,0.0002450022,0.0005023195,0.0005064157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004357203,"about_ca_system_score_gemma":0.0001782133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009491334,"about_ca_topic_score_gemma":0.0006289335,"domain_scores_codex":[0.9997531,0.0000355645,0.00003541666,0.00006370422,0.00007716861,0.00003517437],"domain_scores_gemma":[0.9998023,0.00002868893,0.00006582092,0.00002657542,0.00003473928,0.00004195783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056827,0.00002994285,0.0002702152,0.00004848279,0.000007737275,0.00002029914,0.00001554375,0.00004937363,0.998418,0.00003557654,0.00003021669,0.0009689071],"study_design_scores_gemma":[0.00001348072,0.0001238535,0.003145231,0.000004577442,0.000008433581,0.0003792275,0.00001661276,0.0005362298,0.99369,0.00001861198,0.002057378,0.000006370659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929948,0.001061779,0.004216651,0.0000964807,0.00002989893,0.00003945015,0.0009169145,0.000118152,0.0005258347],"genre_scores_gemma":[0.9840325,0.0006013281,0.00768012,0.0000427824,0.00001074811,0.00004214917,0.005105199,0.0000717418,0.00241342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009491334,"threshold_uncertainty_score":0.00316143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171137393635429,"score_gpt":0.2297622034220056,"score_spread":0.2180508294856513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}