{"id":"W2315034049","doi":"10.1021/bc200284b","title":"Synthetic Modification of Carboxymethylcellulose and Use Thereof to Prepare a Nanoparticle Forming Conjugate of Docetaxel for Enhanced Cytotoxicity against Cancer Cells","year":2011,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Chemistry; Conjugate; Nanoparticle; Docetaxel; Ethylene glycol; PEGylation; PEG ratio; Cytotoxicity; Solubility; Drug delivery; Nanocarriers; Combinatorial chemistry; Nuclear chemistry; Nanotechnology; Organic chemistry; In vitro; Polyethylene glycol; Biochemistry; Cancer; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003883508,0.000221119,0.0003774399,0.00003632547,0.0000675818,0.00002708561,0.0002581022,0.000106682,0.0001018882],"category_scores_gemma":[0.000157327,0.0002110473,0.00008257019,0.0001490147,0.0002339369,0.0002153381,0.0001079025,0.0000452605,0.000007324742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006338822,"about_ca_system_score_gemma":0.0001039975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003147823,"about_ca_topic_score_gemma":0.00001790788,"domain_scores_codex":[0.9982984,0.00004162173,0.0005837728,0.0005035719,0.0001979495,0.0003746552],"domain_scores_gemma":[0.9984735,0.0001357326,0.0003801402,0.0005466666,0.0002843147,0.0001796073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004273817,0.0001821461,0.0001158828,0.0004930294,0.00001988527,9.67135e-7,0.00128963,0.0001086504,0.9970745,0.00002278574,0.00001631675,0.0002488417],"study_design_scores_gemma":[0.0007294951,0.00008526607,0.00006436435,0.0001645718,0.00005882574,7.636638e-7,0.0002458118,0.0006026907,0.9977167,0.00006865696,0.00002534535,0.0002375005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979995,0.0001236212,0.0003689746,0.00001643769,0.000072781,0.0008230666,0.0004058966,0.00004901682,0.0001406413],"genre_scores_gemma":[0.9973973,0.00003742812,0.002091166,0.00004426578,0.00002423318,0.0002749503,0.000005220576,0.00003078957,0.00009465001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722192,"threshold_uncertainty_score":0.8606258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03334120934792152,"score_gpt":0.256151297523053,"score_spread":0.2228100881751315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}