{"id":"W2315120195","doi":"10.2174/1567205013666160404120542","title":"Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease","year":2016,"lang":"en","type":"review","venue":"Current Alzheimer Research","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"Veterans Affairs Canada","funders":"Canadian Institutes of Health Research","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Neuroscience; Cholinergic; Dementia; Neurotransmitter; Acetylcholine; Alzheimer's disease; Cholinesterase; Psychology; Medicine; Aché; Disease; Internal medicine; Chemistry; Central nervous system; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004101492,0.0004460801,0.0003966385,0.0003874553,0.0001710521,0.0004844289,0.0002880773,0.0007837113,0.001250264],"category_scores_gemma":[0.0002348654,0.0001417721,0.0002797937,0.0002483608,0.0003831188,0.0003773968,0.0002500124,0.001085669,0.0004967293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004045806,"about_ca_system_score_gemma":0.0003966871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005680329,"about_ca_topic_score_gemma":0.001025854,"domain_scores_codex":[0.999842,0.00003813002,0.0000105569,0.00002892571,0.00005647819,0.00002382295],"domain_scores_gemma":[0.9999044,0.00001782399,0.00002150816,0.000008949514,0.00002607003,0.00002127159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007173548,0.0003566834,0.001329332,0.001018337,0.00008475167,0.0007405985,0.00009215073,0.0006853663,0.8382311,0.003061444,0.003357649,0.1503253],"study_design_scores_gemma":[0.0003608429,0.005046399,0.007372661,0.0003340276,0.0004602311,0.006355177,0.0001125374,0.002935958,0.7858595,0.002514144,0.188576,0.00007250385],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2327257,0.7184532,0.0251186,0.00689049,0.001193345,0.0002408981,0.0003686583,0.0003451727,0.01466383],"genre_scores_gemma":[0.7014039,0.2646407,0.01964629,0.002441072,0.000526373,0.0001382947,0.0005910212,0.00003891139,0.0105735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001250264,"threshold_uncertainty_score":0.004182577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3932117321800884,"score_gpt":0.5374206331975706,"score_spread":0.1442089010174822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}