{"id":"W2315143269","doi":"10.1021/la501660u","title":"Binding of a Monoclonal Antibody to the Phospholamban Cytoplasmic Domain Interferes with the Channel Activity of Phospholamban Reconstituted in a Tethered Bilayer Lipid Membrane","year":2014,"lang":"en","type":"article","venue":"Langmuir","topic":"Analytical Chemistry and Sensors","field":"Chemical Engineering","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Ente Cassa di Risparmio di Firenze","keywords":"Phospholamban; Pentamer; Endoplasmic reticulum; Biophysics; Lipid bilayer; Chemistry; Ion channel; Translocon; Calsequestrin; Bilayer; Membrane protein; Cytoplasm; Ryanodine receptor; Membrane; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004877374,0.00048259,0.0003739004,0.0002092664,0.0001777106,0.0003161519,0.0006609188,0.000696581,0.0007524438],"category_scores_gemma":[0.0004331,0.0002400175,0.0003219242,0.0002044724,0.0004067557,0.0002556615,0.0002395939,0.001073397,0.0002247151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000494769,"about_ca_system_score_gemma":0.0002521261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007761613,"about_ca_topic_score_gemma":0.0007439287,"domain_scores_codex":[0.9993811,0.0001430959,0.00004804328,0.000117021,0.0001690972,0.0001417054],"domain_scores_gemma":[0.9996197,0.0001681157,0.00006140339,0.00004890124,0.00004560089,0.00005621568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006136408,0.00004681651,0.00004067147,0.00001548397,0.000005051146,0.00001575711,0.0000112528,0.00003283978,0.999569,0.00003320795,0.00001066803,0.000157937],"study_design_scores_gemma":[0.0000117198,0.0001466104,0.0004950752,0.00000188932,0.000006802718,0.00002541931,0.000007193357,0.001020672,0.9981681,0.00001192048,0.0001027556,0.000001844572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971226,0.000243217,0.001998059,0.0001045693,0.00004198372,0.00001500219,0.00004693759,0.00004257173,0.0003851776],"genre_scores_gemma":[0.9956996,0.0002467338,0.002859763,0.00008885052,0.00001248113,0.00003601328,0.0001314431,0.00001961715,0.00090549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007761613,"threshold_uncertainty_score":0.003589749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069004825073903,"score_gpt":0.2315636779932815,"score_spread":0.2208736297425425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}