{"id":"W2315143269","doi":"10.1021/la501660u","title":"Binding of a Monoclonal Antibody to the Phospholamban Cytoplasmic Domain Interferes with the Channel Activity of Phospholamban Reconstituted in a Tethered Bilayer Lipid Membrane","year":2014,"lang":"en","type":"article","venue":"Langmuir","topic":"Analytical Chemistry and Sensors","field":"Chemical Engineering","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Ente Cassa di Risparmio di Firenze","keywords":"Phospholamban; Pentamer; Endoplasmic reticulum; Biophysics; Lipid bilayer; Chemistry; Ion channel; Translocon; Calsequestrin; Bilayer; Membrane protein; Cytoplasm; Ryanodine receptor; Membrane; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003175116,0.0001847785,0.0003500511,0.00005186216,0.00005096148,0.00001262576,0.0003420945,0.0000984322,0.00006405048],"category_scores_gemma":[0.0001206647,0.000101741,0.00008797596,0.0004089002,0.0001375038,0.00005531891,0.00007357154,0.0003351617,0.000008389608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003495222,"about_ca_system_score_gemma":0.00001914399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002311295,"about_ca_topic_score_gemma":0.0001048111,"domain_scores_codex":[0.9990193,0.00004967541,0.0002415619,0.0002304938,0.0001914865,0.0002674914],"domain_scores_gemma":[0.9991801,0.00029096,0.0001060621,0.000322181,0.00003946135,0.00006128269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004568446,0.00008167393,0.0007989871,0.00008237572,0.00007675648,0.000004538994,0.001315939,0.001987827,0.9943569,0.000480455,0.00006598076,0.0002917534],"study_design_scores_gemma":[0.0005823587,0.00006454843,0.0009336687,0.0001600406,0.00002583446,0.00001104258,0.0004227358,0.01076847,0.985799,0.00002860686,0.001032554,0.0001711262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950694,0.00002137558,0.001908684,0.0009550661,0.00003328018,0.0001567475,0.00002544084,0.00002990333,0.001800136],"genre_scores_gemma":[0.9994001,0.000003957259,0.0001598106,0.00006407009,0.0000643259,0.00001303544,0.000007365177,0.00001947242,0.0002678835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00878064,"threshold_uncertainty_score":0.4148878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069004825073903,"score_gpt":0.2315636779932815,"score_spread":0.2208736297425425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}