{"id":"W2315218881","doi":"10.1021/jo1015344","title":"Stereoselective Synthesis of 2,3,6-Trisubstituted Tetrahydropyridines via Tf<sub>2</sub>O-Mediated Grob Fragmentation: Access to Indolizidines (−)-209I and (−)-223J","year":2010,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Stereoselectivity; Chemistry; Reagent; Fragmentation (computing); Combinatorial chemistry; Stereochemistry; Organic chemistry; Catalysis; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003804083,0.0003283711,0.0005145374,0.0001015708,0.0001500245,0.00007079348,0.0007494376,0.0002539194,0.0009053411],"category_scores_gemma":[0.0009874485,0.0002542541,0.0001181589,0.0005451585,0.000145001,0.0003140676,0.0001899517,0.0008145284,0.00001036791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303579,"about_ca_system_score_gemma":0.0002104525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001450948,"about_ca_topic_score_gemma":0.00002146476,"domain_scores_codex":[0.9980819,0.00003553511,0.0007879766,0.0002465544,0.000554412,0.0002936666],"domain_scores_gemma":[0.9972038,0.0006037828,0.0009516044,0.0004230892,0.0005628915,0.0002547771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002643632,0.0001113799,0.0008096803,0.0002636107,0.0001786635,0.00001568913,0.000547561,0.000009653334,0.9941244,8.911728e-7,0.0001155454,0.003558567],"study_design_scores_gemma":[0.000747684,0.00003232268,0.0006823755,0.000146777,0.0002557574,0.001082947,0.0009138367,0.00002667654,0.9956349,0.00008631179,0.0001312587,0.0002591776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983502,0.0001830922,0.0003230442,0.0003383029,0.0002208824,0.0001163818,0.00002415083,0.00004266353,0.000401265],"genre_scores_gemma":[0.9988332,0.0002929256,0.0002030058,0.00004250363,0.0005284817,0.000007856838,0.000007995268,0.00005732861,0.00002667434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00329939,"threshold_uncertainty_score":0.9999909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007876115742240484,"score_gpt":0.2323334317615269,"score_spread":0.2244573160192864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}