{"id":"W2315278210","doi":"10.1515/bc.2010.140","title":"Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin","year":2010,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Renin–angiotensin system; Endocrinology; Internal medicine; Cathepsin B; Cathepsin; Chemistry; Plasma renin activity; Zymogen; Activator (genetics); Cathepsin H; Cathepsin D; Cathepsin L1; Blood pressure; Enzyme; Biology; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003121825,0.0002822191,0.0002621528,0.0004896148,0.0001241839,0.000312206,0.0003216327,0.0003990782,0.002262751],"category_scores_gemma":[0.0004568521,0.0002021408,0.0001800163,0.0001714858,0.0005357374,0.0003857277,0.000165351,0.0005551981,0.000345866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124528,"about_ca_system_score_gemma":0.0002046573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003889658,"about_ca_topic_score_gemma":0.0004931831,"domain_scores_codex":[0.9998233,0.00002469961,0.00002496689,0.00005397428,0.00004164331,0.00003152324],"domain_scores_gemma":[0.9994349,0.0001008213,0.000204445,0.0000761573,0.00004786718,0.0001357582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006014021,0.00004737672,0.001022453,0.00008394188,0.00002511943,0.0002180343,0.00001481726,0.00003239286,0.994149,0.0005871461,0.00004944223,0.003168771],"study_design_scores_gemma":[0.0002324384,0.002029928,0.03746753,0.00004409225,0.0002199119,0.008122337,0.00009611501,0.0008495478,0.9418421,0.0009316764,0.008141659,0.00002264678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883061,0.004876238,0.003742808,0.0003138841,0.00003567656,0.00001491447,0.0002853185,0.00006042453,0.002364594],"genre_scores_gemma":[0.9907553,0.002894535,0.003875177,0.0001421244,0.00003426862,0.00002480637,0.0006128547,0.00002567823,0.001635349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262751,"threshold_uncertainty_score":0.007569611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1094305004918709,"score_gpt":0.3341848979399004,"score_spread":0.2247543974480296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}