{"id":"W2315278210","doi":"10.1515/bc.2010.140","title":"Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin","year":2010,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Renin–angiotensin system; Endocrinology; Internal medicine; Cathepsin B; Cathepsin; Chemistry; Plasma renin activity; Zymogen; Activator (genetics); Cathepsin H; Cathepsin D; Cathepsin L1; Blood pressure; Enzyme; Biology; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002193134,0.00024653,0.0005203233,0.000009405289,0.0001009567,0.00001325779,0.0002430247,0.0003458058,0.0003400367],"category_scores_gemma":[0.0009148935,0.0001112739,0.000163597,0.0000968555,0.0009600837,0.00002180632,0.0002889731,0.0005049244,0.00001029974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002123349,"about_ca_system_score_gemma":0.00003837641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009592272,"about_ca_topic_score_gemma":2.702051e-7,"domain_scores_codex":[0.9985675,0.00006800122,0.0003086577,0.0004985198,0.0002617493,0.0002956149],"domain_scores_gemma":[0.9987794,0.0004168318,0.0002149254,0.0003358166,0.0001085815,0.0001444637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002234363,0.0001010857,0.08881847,0.00003055715,0.00007068862,0.00002428968,0.00007367542,1.132731e-7,0.9088166,0.000003904309,0.001004377,0.0008328088],"study_design_scores_gemma":[0.0002527337,0.0001456039,0.4543058,0.00004342653,0.00005655124,0.0001316717,0.00002952416,0.0000147958,0.5443106,0.00002117803,0.0005924426,0.00009570734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951102,0.001068219,0.000006988751,0.003063905,0.00008709956,0.0004013803,0.00001463657,0.00005456931,0.0001930033],"genre_scores_gemma":[0.9980046,0.0003425052,0.0006013595,0.0004720598,0.0003246006,0.0000649406,0.00000341588,0.00000860305,0.0001778934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3654873,"threshold_uncertainty_score":0.4537617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1094305004918709,"score_gpt":0.3341848979399004,"score_spread":0.2247543974480296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}