{"id":"W2315305182","doi":"10.1136/annrheumdis-2013-eular.1127","title":"THU0599 From Bad to Worse? The Impact of Switching Biologic Agents Multiple Times on Work Productivity and Health-Related Quality of Life for Patients with RA.","year":2013,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Golimumab; Adalimumab; Abatacept; Etanercept; Rheumatoid arthritis; Tocilizumab; Physical therapy; Infliximab; Internal medicine; Cohort; Work productivity; Quality of life (healthcare); Certolizumab pegol; Rheumatology; Productivity; Rituximab; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005780311,0.000153878,0.000564941,0.0000354994,0.0001064433,0.000007305944,0.000247512,0.00007373003,0.0001170009],"category_scores_gemma":[0.002167025,0.00006347658,0.0001966198,0.0001603576,0.0002385428,0.00004443197,0.0001011793,0.0000864101,0.000003102059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000749274,"about_ca_system_score_gemma":0.0000512141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001949102,"about_ca_topic_score_gemma":0.00001654151,"domain_scores_codex":[0.9983754,0.0006214764,0.0005267983,0.0002035396,0.0000617512,0.0002110499],"domain_scores_gemma":[0.9974694,0.001339025,0.0005862884,0.0004054676,0.0001451024,0.00005475611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001752759,0.001436152,0.9522723,0.0001498452,0.001354944,1.264382e-8,0.0004850578,0.00006158186,0.000589926,0.00007200116,0.007674961,0.03415045],"study_design_scores_gemma":[0.0006783929,0.0006126463,0.9950373,0.0003513687,0.00004112352,4.450425e-8,0.0000796418,0.00001848652,0.001071881,0.002020599,0.000006847003,0.00008172512],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943649,0.00120176,0.00004104135,0.002840936,0.00008783242,0.001087872,0.0003583563,0.000008260227,0.000009052333],"genre_scores_gemma":[0.9994599,0.00003280691,0.0001754743,0.00023103,0.000003839344,0.00002727946,0.00001984143,0.000007238984,0.00004261434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04276493,"threshold_uncertainty_score":0.2946473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0866449699528848,"score_gpt":0.3585350082056694,"score_spread":0.2718900382527846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}